Porcine reproductive and respiratory syndrome virus attachment is mediated by the N-terminal domain of the sialoadhesin receptor

文献类型： 外文期刊

第一作者： Tong, Guang-Zhi

作者： Tong, Guang-Zhi;An, Tong-Qing;Tian, Zhi-Jun;He, Yun-Xia;Xiao, Yan;Jiang, Yi-Feng;Peng, Jin-Mei;Zhou, Yan-Jun;Tong, Guang-Zhi;An, Tong-Qing;Liu, Di

作者机构：

关键词： Porcine reproductive and respiratory syndrome virus (PRRSV);Receptor;Sialoadhesin;Binding domain

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

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收录情况： SCI

摘要： Sialoadhesin (Sn) is an important receptor for viral attachment and internalization of porcine reproductive and respiratory syndrome virus (PRRSV) to porcine alveolar macrophages (PAM). To investigate whether the NI-terminal domain of Sn is sufficient and/or necessary for PRRSV attachment, we constructed a series of truncated fragments of porcine Sn and expressed these in the non-permissive PK15 cell line. The first 150 amino acids comprising the entire first domain of the Sn N-terminal region was necessary for PRRSV binding, to cells, and the N-terminal domain alone was sufficient for virus attachment. The attachment of PRRSV to PAM cells was inhibited by polyclonal anti-serum against the N-terminal region of porcine Sn in a dose-dependent manner. The present study demonstrates that the first domain at the N-terminus of Sn mediates PRRSV attachment to PAM cells and contributes to better understanding the interaction between PRRSV and its host cells. (C) 2009 Elsevier B.V. All rights reserved.

分类号： S8

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