Antisera-mediated in vivo reduction of Cry1Ac toxicity in Helicoverpa armigera

文献类型： 外文期刊

第一作者： Gao, Yulin

作者： Gao, Yulin;Ning, Changming;Wu, Kongming;Guo, Yuyuan;Ning, Changming;Oppert, Brenda

作者机构：

关键词： Toxicology;Pest Assessment Control and Management

期刊名称：JOURNAL OF INSECT PHYSIOLOGY （ 影响因子：2.354； 五年影响因子：3.045 ）

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收录情况： SCI

摘要： A functional assessment of Bacillus thuringiensis (Bt) toxin receptors in the midgut of lepidopteran insects will facilitate understanding of the toxin mode of action and provide effective strategies to counter the development of resistance. In this study, we produced anti-aminopeptidase (APN) and anti-cadherin sera with purified Cry1Ac toxin-binding APN or cadherin fragments from Heliocoverpa armigera. Antisera were evaluated for their effects on Cry1Ac toxicity through bioassays. Our results indicated that both the anti-APN and anti-cadherin sera reduced Cry1Ac toxicity in vivo, although cadherin antiserum reduced toxicity more than APN antiserum. These results suggest that both APN and cadherin are involved in Cry1Ac intoxication of H. armigera, evidence that the pore formation model may be representative of Cry1Ac toxin mode of action in this insect. (C) 2009 Elsevier Ltd. All rights reserved.

分类号： Q965

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