Genetic Association of APOA5 and AKT3 Genes with Milk Production Traits in Chinese Holstein Cows
文献类型： 外文期刊
第一作者： Guo, Zijiao
作者： Guo, Zijiao;Du, Aixia;Han, Bo;Xu, Lingna;Sun, Dongxiao;Li, Hui;Tian, Rugang;Tian, Jing;Sun, Wei;Zhao, Gaoping;Bao, Xiangnan;Zhang, Jixin
作者机构：
关键词： APOA5; AKT3; milk production traits; association analysis; SNP
期刊名称：AGRICULTURE-BASEL （ 影响因子：3.3； 五年影响因子：3.5 ）
ISSN：
年卷期： 2024 年 14 卷 6 期
页码：
收录情况： SCI
摘要： Genome selection (GS) technology is an important means to improve the genetic improvement of dairy cows, and the mining and application of functional genes and loci for important traits is one of the important bases for accelerating genetic improvement. Our previous study found that the apolipoprotein A5 (APOA5) and AKT serine/threonine kinase 3 (AKT3) genes were differentially expressed in the liver tissue of Chinese Holstein cows at different lactation stages and influenced milk component synthesis and metabolism, so we considered these two genes as the candidates affecting milk production traits. In this study, we found in total six single nucleotide polymorphisms (SNPs), three in APOA5 and three in AKT3. Subsequent association analysis showed that the six SNPs were significantly associated with milk yield, fat yield, protein yield, or fat percentage (p <= 0.05). Three SNPs in APOA5 formed a haplotype block, which was found to be significantly associated with milk yield, fat yield, and protein yield (p <= 0.05). In addition, four SNPs were proposed to be functional mutations affecting the milk production phenotype, of which three, 15:g.27446527C>T and 15:g.27447741A>G in APOA5 and 16:g.33367767T>C in AKT3, might change the transcription factor binding sites (TFBSs), and one is a missense mutation, 15:g.27445825T>C in APOA5, which could alter the secondary structure and stability of mRNA and protein. In summary, we demonstrated the genetic effects of APOA5 and AKT3 on milk production traits, and the valuable SNPs could be used as available genetic markers for dairy cattle's GS.
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