Genetic Association of APOA5 and AKT3 Genes with Milk Production Traits in Chinese Holstein Cows

文献类型: 外文期刊

第一作者: Guo, Zijiao

作者: Guo, Zijiao;Du, Aixia;Han, Bo;Xu, Lingna;Sun, Dongxiao;Li, Hui;Tian, Rugang;Tian, Jing;Sun, Wei;Zhao, Gaoping;Bao, Xiangnan;Zhang, Jixin

作者机构:

关键词: APOA5; AKT3; milk production traits; association analysis; SNP

期刊名称:AGRICULTURE-BASEL ( 影响因子:3.3; 五年影响因子:3.5 )

ISSN:

年卷期: 2024 年 14 卷 6 期

页码:

收录情况: SCI

摘要: Genome selection (GS) technology is an important means to improve the genetic improvement of dairy cows, and the mining and application of functional genes and loci for important traits is one of the important bases for accelerating genetic improvement. Our previous study found that the apolipoprotein A5 (APOA5) and AKT serine/threonine kinase 3 (AKT3) genes were differentially expressed in the liver tissue of Chinese Holstein cows at different lactation stages and influenced milk component synthesis and metabolism, so we considered these two genes as the candidates affecting milk production traits. In this study, we found in total six single nucleotide polymorphisms (SNPs), three in APOA5 and three in AKT3. Subsequent association analysis showed that the six SNPs were significantly associated with milk yield, fat yield, protein yield, or fat percentage (p <= 0.05). Three SNPs in APOA5 formed a haplotype block, which was found to be significantly associated with milk yield, fat yield, and protein yield (p <= 0.05). In addition, four SNPs were proposed to be functional mutations affecting the milk production phenotype, of which three, 15:g.27446527C>T and 15:g.27447741A>G in APOA5 and 16:g.33367767T>C in AKT3, might change the transcription factor binding sites (TFBSs), and one is a missense mutation, 15:g.27445825T>C in APOA5, which could alter the secondary structure and stability of mRNA and protein. In summary, we demonstrated the genetic effects of APOA5 and AKT3 on milk production traits, and the valuable SNPs could be used as available genetic markers for dairy cattle's GS.

分类号:

  • 相关文献
作者其他论文 更多>>
  • Impact of residual antibiotics on microbial decomposition of livestock manures in Eutric Regosol: Implications for sustainable nutrient recycling and soil carbon sequestration

    作者:Fang, Linfa;Lakshmanan, Prakash;Su, Xiaoxuan;Shi, Yujia;Chen, Zheng;Zhang, Yu;Xiao, Ran;Chen, Xinping;Lakshmanan, Prakash;Wu, Junxi;Lakshmanan, Prakash;Lakshmanan, Prakash;Sun, Wei

    关键词:Residual antibiotics; Livestock manure decomposition; Microbial community; Co -occurrence network; Enzyme activities

  • A ratiometric fluorescent probe for the determination of quinolone antibiotics in milk based on N and S co-doped carbon quantum dots

    作者:Wang, Fang;Li, Xiaoyun;Zhang, Yuchen;Li, Hui;Jiang, Shanxue;Li, Dandan;Yao, Zhiliang;Wang, Fang;Li, Xiaoyun;Zhang, Yuchen;Li, Hui;Jiang, Shanxue;Li, Dandan;Yao, Zhiliang;Wang, Fang;Li, Xiaoyun;Zhang, Yuchen;Li, Hui;Jiang, Shanxue;Li, Dandan;Yao, Zhiliang;Han, Jiajun;Gong, Wenwen

    关键词:Carbon quantum dot; Ratiometric fluorescence probe; Moxifloxacin; Gatifloxacin; Ofloxacin; Milk

  • Integrated transcriptome and DNA methylome analysis reveal the biological base of increased resistance to gray leaf spot and growth inhibition in interspecific grafted tomato scions

    作者:Liu, Ce;He, Lixia;Wang, Chunguo;Jia, Yanhong;Song, Jian;Ji, Lizhu;Li, Hui

    关键词:Tomato; Grafting; Gray leaf spot; Growth-defense tradeoff

  • Extreme drought impacts have been underestimated in grasslands and shrublands globally

    作者:Smith, Melinda D.;Knapp, Alan K.;Ohlert, Timothy;Smith, Melinda D.;Knapp, Alan K.;Wilkins, Kate D.;Holdrege, Martin C.;Beard, Karen H.;Kulmatiski, Andrew;Holdrege, Martin C.;Beard, Karen H.;Kulmatiski, Andrew;Wilfahrt, Peter;Anderson, Maggie;Borer, Elizabeth T.;Isbell, Forest;Seabloom, Eric W.;Collins, Scott L.;Sala, Osvaldo E.;Jordan, Samuel;Dukes, Jeffrey S.;Phillips, Richard P.;Beier, Claus;Yahdjian, Laura;Biancari, Lucio;Bondaruk, Viviana Florencia;Onatibia, Gaston R.;Pineiro-Guerra, Juan Manuel;Gherardi, Laureano A.;Larsen, Klaus Steenberg;Fraser, Lauchlan H.;Jentsch, Anke;Niu, Yujie;Loik, Michael E.;Maestre, Fernando T.;Valdecantos, Alejandro;Maestre, Fernando T.;Gozalo, Beatriz;Maturano-Ruiz, Adrian;Valdecantos, Alejandro;Power, Sally A.;Chieppa, Jeff;Nielsen, Uffe N.;Yu, Qiang;Felton, Andrew J.;Munson, Seth M.;Luo, Yiqi;Bauerle, Taryn;Abdoli, Hamed;Abedi, Mehdi;Bahalkeh, Khadijeh;Alados, Concepcion L.;Castillo-Garcia, Miguel;Pueyo, Yolanda;Alberti, Juan;Bruschetti, Carlos Martin;Cardoni, Augusto;Daleo, Pedro;Iribarne, Oscar;Alon, Moshe;Cohen, Ofer;Sternberg, Marcelo;An, Hui;Anacker, Brian;Auge, Harald;Auge, Harald;Eisenhauer, Nico;Hoss, Daniela;Roscher, Christiane;Sunnemann, Marie;Bachle, Seton;Bachle, Seton;Bahn, Michael;Ingrisch, Johannes;Batbaatar, Amgaa;Cahill, James F., Jr.;Batbaatar, Amgaa;Bork, Edward W.;Carlyle, Cameron N.;Behn, Kai;Beil, Ilka;Kreyling, Juergen;Malyshev, Andrey V.;Blindow, Irmgard;Dahlke, Sven;Byrne, Kerry M.;Calvo, Dianela A.;Leder, Cintia V.;Peter, Guadalupe;Carbognani, Michele;Forte, T'ai G. W.;Petraglia, Alessandro;Chang, Scott X.;Cianciaruso, Marcus V.;Guidoni-Martins, Karlo G.;Nobre, Paola;Cordeiro, Amanda L.;Cusack, Daniela F.;Dietterich, Lee H.;D'Antonio, Carla M.;Dietterich, Lee H.;Doherty, Tim S.;Greenville, Aaron C.;Wardle, Glenda M.;Dubbert, Maren;Ebeling, Anne;Eisenhauer, Nico;Fischer, Felicia M.;Hoss, Daniela;Sunnemann, Marie;Hoss, Daniela;Pillar, Valerio D.;Fischer, Felicia M.;Gebauer, Tobias;Anacker, Brian;Haugum, Siri Vatso;Vandvik, Vigdis;Hautier, Yann;Hefting, Mariet;Henry, Hugh A. L.;Johnson, Yari;Kelly, Eugene F.;Kimmel, Kaitlin;Kroel-Dulay, Gyorgy;Orban, Ildiko;Kroel-Dulay, Gyorgy;Orban, Ildiko;Kubert, Angelika;Werner, Christiane;Lamb, Eric G.;Larson, Julie;O'Connor, Rory C.;Lawson, Jason;Plowes, Robert M.;Linstadter, Anja;Orban, Ildiko;Liu, Jielin;Liu, Shirong;Longo, Grisel;Loydi, Alejandro;Rodriguez, Dana Aylen;Scarfo, Maria Cecilia;Luan, Junwei;Wang, Yi;Luan, Junwei;Wang, Yi;Lubbe, Frederick Curtis;Wiehl, Georg;Mackie-Haas, Kathleen;Stampfi, Andreas;Merchant, Thomas;Metcalfe, Daniel B.;Mori, Akira S.;Mori, Akira S.;Mudongo, Edwin;Newman, Gregory S.;Souza, Lara;Nimmo, Dale;Ogaya, Roma;Penuelas, Josep;Osborne, Brooke;Otfinowski, Rafael;Partel, Meelis;Pineiro-Guerra, Juan Manuel;Peri, Pablo L.;Picon-Cochard, Catherine;Pineiro-Guerra, Juan Manuel;Ploughe, Laura W.;Portales-Reyes, Cristy;Reed, Sasha C.;Ritchie, Euan G.;Roscher, Christiane;Sanchez, Ana M.;Santo, Braulio A.;Shi, Baoku;Sun, Wei;Souza, Lara;Standish, Rachel J.;Zeiter, Michaela;Stampfi, Andreas;Zeiter, Michaela;Standish, Rachel J.;Tedder, Michelle;Thorvaldsen, Pal;Tian, Dashuan;Zhu, Juntao;Zong, Ning;Tielborger, Katja;van den Brink, Liesbeth;Vankoughnett, Mathew R.;Velle, Liv Guri;Wang, Changhui;Wei, Cunzheng;Williams, Jennifer L.;Wolf, Amelia A.;Zhang, Fawei;Zuo, Xiaoan;Zuo, Xiaoan;Gebauer, Tobias;Ploughe, Laura W.

    关键词:climate extreme; Drought-Net; International Drought Experiment; productivity

  • Mechanisms on salt tolerant of Paenibacillus polymyxa SC2 and its growth-promoting effects on maize seedlings under saline conditions

    作者:Wang, Chengqiang;Pei, Jian;Li, Hui;Zhu, Xiuling;Zhang, Yanan;Li, Wenjie;Wang, Zhongyue;Liu, Kai;Du, Binghai;Zhao, Dongying;Zhao, Dongying;Jiang, Juquan;Wang, Yanjun

    关键词:Paenibacillus polymyxa; Salt -tolerance; Transcriptome; Maize

  • Promoter replication of grape MYB transcription factor is associated with a new red flesh phenotype

    作者:Li, Hui;Yang, Yaxin;Zheng, Huan;Xu, Xianbin;Li, Haoran;Sun, Chenxu;Hu, Haipeng;Zhao, Wanli;Ma, Ruiyang;Tao, Jianmin;Zhang, Wen;Tao, Jianmin;Li, Hui

    关键词:Teinturier grape; Anthocyanin; VvMYBA1; Repetitive fragment

  • Rosemary leaf powder improves egg quality, antioxidant status, gut barrier function, and cecal microbiota and metabolites of late-phase laying hens

    作者:Zhang, Lianhua;Ge, Junwei;Gao, Fei;Yang, Min;Li, Hui;Xia, Fei;Bai, Hongtong;Shi, Lei;Zhang, Lianhua;Ge, Junwei;Gao, Fei;Yang, Min;Li, Hui;Xia, Fei;Bai, Hongtong;Shi, Lei;Zhang, Lianhua;Ge, Junwei;Yang, Min;Sun, Zhiying;Gao, Fei;Piao, Xiangshu;Piao, Xiangshu

    关键词:Rosemary leaf powder; Production; Antioxidant status; Gut health; Microbial community; Laying hen