Mesoporous silica nanoparticles enhance the toxicity of chlorantraniliprole to Spodoptera frugiperda by possibly inhibiting energy metabolism and chitin protein synthesis

文献类型： 外文期刊

第一作者： Zong, Suman

作者： Zong, Suman;Xu, Dejin;Jiang, Yiping;Zhang, Xin;Zhao, Jing;Xiao, Liubin;Xu, Guangchun;Tan, Yongan;Zong, Suman;Ge, Linquan;Wang, Xiaofeng;Zhu-Salzman, Keyan;Zhang, Leigang;Gu, Aiguo;Hong, Hao

作者机构：

关键词： chlorantraniliprole; foliage adhesion; mesoporous silica nanoparticles; RNA-Seq; Spodoptera frugiperda

期刊名称：INSECT SCIENCE （ 影响因子：3.0； 五年影响因子：3.5 ）

ISSN： 1672-9609

年卷期： 2025 年

页码：

收录情况： SCI

摘要： Nanosized formulations are an important means to develop effective pesticide molecules against target pests with improved environmental safety. In this study, we constructed a nanodelivery system using mesoporous silica nanoparticles (MSNs) carrying chlorantraniliprole (CLAP). The drug loading rate was determined using liquid chromatography, and CLAP@MSNs were characterized and analyzed. Adhesion was measured by contact angle and surface tension, and UV resistance was assessed. The transport of CLAP@MSNs within plants was observed using confocal fluorescence microscopy. Additionally, larval bioassay experiments and RNA-seq analyses were conducted on CLAP@MSNs. The results indicate that CLAP (35.6% w/w) has been successfully loaded onto MSNs. CLAP@MSNs appeared to have structure and size similar to MSNs. CLAP@MSNs showed effective adhesion to the surface of corn leaves and stems and also resisted to UV photolysis. Bidirectional delivery of fluorescently labeled CLAP@MSNs through vascular bundles in corn. When administered to Spodoptera frugiperda, mortality in CLAP@MSNs-treated larvae increased whereas weight and developmental period decreased significantly compared with larvae treated with CLAP alone. RNA-seq analysis revealed that oral administration of CLAP@MSNs led to the downregulation of genes associated with drug metabolism, energy metabolism, and chitin protein synthesis, thereby inhibiting the growth and development of insects. Interestingly, CLAP@MSNs exerted no harmful effects on growth of plants and development of non-target organisms. Taken together, CLAP@MSNs provide a safe, effective, and economical insecticidal nanopesticide system that potentially further improves the effectiveness of CLAP against lepidopteran pests, contributing to the reduction of pesticide use in pest management.

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