PPanG: a precision pangenome browser enabling nucleotide-level analysis of genomic variations in individual genomes and their graph-based pangenome

文献类型： 外文期刊

第一作者： Liu, Mingwei

作者： Liu, Mingwei;Lu, Huimin;Xue, Hongzhang;Dong, Xiaorui;Wei, Chaochun;Zhang, Fan;Li, Zhikang;Xu, Jianlong;Wang, Wensheng;Zhang, Fan;Li, Zhikang;Wang, Wensheng;Wang, Wensheng

作者机构：

关键词： Genome browser; Graph pangenome; Genome annotation; Comparative pangenomics; Rice

期刊名称：BMC GENOMICS （ 影响因子：4.4； 五年影响因子：4.7 ）

ISSN： 1471-2164

年卷期： 2024 年 25 卷 1 期

页码：

收录情况： SCI

摘要： Graph-based pangenome is gaining more popularity than linear pangenome because it stores more comprehensive information of variations. However, traditional linear genome browser has its own advantages, especially the tremendous resources accumulated historically. With the fast-growing number of individual genomes and their annotations available, the demand for a genome browser to visualize genome annotation for many individuals together with a graph-based pangenome is getting higher and higher. Here we report a new pangenome browser PPanG, a precise pangenome browser enabling nucleotide-level comparison of individual genome annotations together with a graph-based pangenome. Nine rice genomes with annotations were provided by default as potential references, and any individual genome can be selected as the reference. Our pangenome browser provides unprecedented insights on genome variations at different levels from base to gene, and reveals how the structures of a gene could differ for individuals. PPanG can be applied to any species with multiple individual genomes available and it is available at https://cgm.sjtu.edu.cn/PPanG.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序