Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens

文献类型： 外文期刊

第一作者： Yuan, Lin

作者： Yuan, Lin;Li, Wanli;Yi, Baodi;Wang, Mingfa;Huo, Qianqian;Du, Chenhong;Wang, Zhixiang

作者机构：

关键词： Broiler; XOS; FLA; Immune-related gene; SCFA

期刊名称：PEERJ （ 影响因子：2.984； 五年影响因子：3.369 ）

ISSN： 2167-8359

年卷期： 2018 年 6 卷

页码：

收录情况： SCI

摘要： This study investigated the effects of xylo-oligosaccharide (XOS) and flavomycin (FLA) on the performance and immune function of broiler chickens. A total of 150 ArborAcres broilers were randomly divided into three groups and fed for six weeks from one day of age in cascade cages. The diets of each test group were (1) a basal diet, (2) the basal diet supplemented with 2 mg/kg FLA, and (3) the basal diet supplemented with 2 mg/kg XOS. At 21 and 42 days, the growth performance index values and short-chain fatty acid (SCFA) concentrations in the cecum were quantified. Furthermore, immunoglobulin G (IgG) and plasma interleukin 2 (IL-2) as well as mRNA expression of LPS-Induced TNF-alpha Factor (LITAF), Toll-like receptor-5 (TLR5) and interferon gamma (IFN gamma) in the jejunum were quantified. The results showed that administration of XOS or FLA to chickens significantly improved the average daily gain. Supplementation with XOS increased acetate and butyrate in the cecum, while FLA supplementation increased propionate in the cecum. An increase in plasma IgG was observed in XOS-fed 21 - day-old broilers, but FLA supplementation decreased IgG in the plasma of 42-day old broilers and increased plasma IL-2. Furthermore, FLA or XOS supplementation do regulated mRNA expression of IFN gamma, LITAF and TLR5. The above data suggest that addition of XOS and FLA to the diet could improve the growth performance of broilers and reduce the expression of cytokine genes by stimulating SCFA.

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