Simultaneous determination of kasugamycin and validamycin-A residues in cereals by consecutive solid-phase extraction combined with liquid chromatography-tandem mass spectrometry

文献类型： 外文期刊

第一作者： Zhang, Hong

作者： Zhang, Hong;Wang, Chenchen;Li, Huidong;Nie, Yan;Fang, Liping;Chen, Zilei;Zhang, Hong;Wang, Chenchen;Li, Huidong;Nie, Yan;Fang, Liping;Chen, Zilei

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关键词： Kasugamycin; validamycin-A; residue; cereals; high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS; MS)

期刊名称：FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT （ 影响因子：3.057； 五年影响因子：2.96 ）

ISSN： 1944-0049

年卷期： 2018 年 35 卷 3 期

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收录情况： SCI

摘要： Two polar aminoglycosides, kasugamycin and validamycin-A, were determined in cereals (brown rice, wheat and corn) by high-performance liquid chromatography-tandem mass spectrometry. The analytes were extracted from samples using methanol and water (70:30, v/v) at pH 5.5, purified using both a hydrophilic-hydrophobic-balanced cartridge and a strong cation-exchange cartridge, and then analysed using multiple reaction monitoring in positive electrospray ionisation mode with a special ReproSil 100 C-18 high-performance liquid chromatography column. This newly proposed method yielded good sensitivity and excellent chromatographic performance. The limits of quantification for kasugamycin and validamycin-A were 4.1 mu g/kg and 1.0 mu g/kg, respectively. The recoveries for both compounds at three fortification levels (4, 100 and 500 mu g/kg for kasugamycin; 1, 10 and 100 mu g/kg for validamycin-A) ranged from 75% to 110%, and the relative standard deviations were below 15%.

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