Crystal structure of peptidoglycan recognition protein SA in Apis mellifera (Hymenoptera: Apidae)

文献类型： 外文期刊

第一作者： Liu, Yanjie

作者： Liu, Yanjie;Zhao, Xiaomeng;Naeem, Muhammad;An, Jiandong

作者机构：

关键词： Apis mellifera; binding pocket; crystal structure; PGRP-SA

期刊名称：PROTEIN SCIENCE （ 影响因子：6.725； 五年影响因子：4.316 ）

ISSN： 0961-8368

年卷期： 2018 年 27 卷 4 期

页码：

收录情况： SCI

摘要： Peptidoglycan recognition protein SA (PGRP-SA) is a key pattern recognition receptor in the insect innate immune system. PGRP-SA can bind to bacterial PGN and activate the Toll pathway, which triggers the expression and release of antimicrobial peptides to prevent bacterial infection. Here, we report the first structure of Apis mellifera PGRP-SA from Hymenoptera at 1.86 angstrom resolution. The overall architecture of Am-PGRP-SA was similar to the Drosophila PGRP-SA; however, the residues involved in PGN binding groove were not conserved, and the binding pocket was narrower. This structure gives insight into PGN binding characteristics in honeybees.

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