文献类型： 外文期刊

第一作者： Yu Min

作者： Yu Min;Fu Ruiyan;Huang Jingjing;Yan Yan;Zhang Fusheng;Yin Junfeng;Xie Ningning;Ma Min

作者机构：

关键词： Rapeseed protein; Zinc chelating peptide; Quantitative structure-activity relationship

期刊名称：CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE （ 影响因子：0.65； 五年影响因子：0.481 ）

ISSN： 0251-0790

年卷期： 2018 年 39 卷 2 期

页码：

收录情况： SCI

摘要： 51 Tripeptides were synthesized and the zinc chelating activities were determined, which formed the database. Then those tripeptides were statistically analysed using 18 amino acid descriptors and partial least squares method. Results showed that the correlation coefficients of the quantitative structure-activity relationship(QSAR) models based on 3 amino acids descriptors met the requirements, which were the descriptor FASGAI, Z and C. And the descriptor FASGAI was the best with R-2=0.8225, Q(2)=0.5818, RMSEE=0.1628, Q(ext)(2)=0.6760, RMSEP=0.2499. Further analysis of the model on descriptor FASGAI revealed that the influence of amino acid position in polypeptide on the zinc chelating activity was N-3 > N-2 > N-1. Meanwhile, the bulky properties of amino acid residues influenced the zinc chelating activity of tripeptides.

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