Neonicotinoid insecticides imidacloprid, guadipyr, and cycloxaprid induce acute oxidative stress in Daphnia magna

文献类型： 外文期刊

第一作者： Qi, Suzhen

作者： Qi, Suzhen;Xue, Xiaofeng;Wu, Liming;Qi, Suzhen;Zhu, Lizhen;Teng, Miaomiao;Wang, Chengju;Wang, Donghui

作者机构：

关键词： Neonicotinoids; Daphnia magna; Toxicity; Oxidative stress; Vitellogenin genes

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.291； 五年影响因子：6.393 ）

ISSN： 0147-6513

年卷期： 2018 年 148 卷

页码：

收录情况： SCI

摘要： Cycloxaprid (CYC) and guadipyr (GUA) are two new and promising neonicotinoid insecticides whose effects on Daphnia magna are as yet unknown. In this study, the acute toxicities of CYC and GUA to D. magna, including immobilization and embryo-hatching inhibition, and their effects on antioxidant enzymes and related gene expression were determined after a 48-h exposure. Imidacloprid (IMI) was evaluated at the same time as a reference agent. The 48-h EC50 values of IMI, GUA, and CYC for neonate immobilization were 13.0-16.5 mg/L and for embryo hatching were 11.3-16.2 mg/L. The specific activity of the enzymes superoxide dismutase (SOD) and catalase (CAT) were interfered by IMI, but not by GUA and CYC, while the activity of acetylcholinesterase (AChE) was significantly increased by IMI, but inhibited by GUA and CYC. The relative expressions of the Sod-Cu/Zn, Sod-Mn, Cat, and Ache genes were usually inhibited by IMI, GUA, and CYC, except for Cat by CYC, Ache by GUA, and Sods by IMI. For vitellogenin genes with a SOD-like domain (Vtg1/2-sod), relative expression was increased by IMI and inhibited by GUA and CYC, indicating that IMI, GUA, and CYC have potential toxicity toward reproduction. CYC and GUA are highly active against IMI-resistant pests, and considering the similar toxicity of IMI to D. magna, CYC and GUA are suitable for use in future integrated pest management systems.

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