文献类型： 外文期刊
第一作者： Cheng, Peipei
作者： Cheng, Peipei;Wang, Chunmei;Lin, Xi;Zhang, Lifang;Fei, Chenzhong;Zhang, Keyu;Zhao, Juan;Lei, Na;Liu, Lili;Mu, Shuhua;Wang, Xiaoyang;Wang, Mi;Zheng, Wenli;Liu, Yingchun;Guo, Chunna;Xue, Feiqun
作者机构：
关键词： Ethanamizuril; Rat; Broiler chickens; Pharmacokinetics; Eimeria tenella
期刊名称：RESEARCH IN VETERINARY SCIENCE （ 影响因子：2.534； 五年影响因子：2.382 ）
ISSN： 0034-5288
年卷期： 2018 年 117 卷
页码：
收录情况： SCI
摘要： Ethanamizuril is a new triazine compound that displays potent anticoccidial activity against chicken coccidiosis caused by Eimeria tenella. We studied the pharmacokinetics of ethanamizuril in rats and chickens after single oral doses of one, two and three times the minimum effective dose Ethanamizuril was readily absorbed at all three doses and the plasma concentration reached was maximal within 5 h and progressively declined over time. The mean peak plasma concentrations (C-max) and the area under the concentration - time curve (AUC) were both dose-dependent. These results provide pharmacokinetic profiles of ethanamizuril for future preclinical studies and clinical use.
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