Diet-dependent changes in the intestinal DNA methylome after introduction of enteral feeding in preterm pigs

文献类型： 外文期刊

第一作者： Pan, Xiaoyu

作者： Pan, Xiaoyu;Sangild, Per Torp;Gong, Desheng;Gao, Fei

作者机构：

关键词： DNA methylation; epigenetic gene regulation; immunity; microbiota; nutrition; preterm birth

期刊名称：EPIGENOMICS （ 影响因子：4.778； 五年影响因子：5.53 ）

ISSN： 1750-1911

年卷期： 2018 年 10 卷 4 期

页码：

收录情况： SCI

摘要： Aim: To examine how enteral feeding affects the intestinal epigenome and gene expression just after preterm birth. Materials & methods: Intestinal tissue from preterm pigs, modeling preterm infants, was collected at birth and 5 days after gradual introduction of infant formula or bovine colostrum. The intestinal tissue was analyzed by reduced representation bisulfite sequencing and real-time qPCR. Results: Relative to colostrum, formula increased bacterial epithelial adherence and lipopolysaccharide binding protein (LBP) expression, which was regulated by promoter methylation. Diet-dependent changes in DNA methylation and/or mRNA expression were related to innate immune response, hypoxia, angiogenesis and epithelial-mesenchymal transition pathways (e.g., TTC38, IL8, C3, HIF1A and VEGFR1). Conclusion: Epigenetic changes may mediate important effects of the first feeding on intestinal development in preterm neonates.

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