Reproductive role of miRNA in the hypothalamic-pituitary axis

文献类型： 外文期刊

第一作者： Cao, Chunyu

作者： Cao, Chunyu;Ding, Yifei;Xiang, Wei;Chen, Long;Yang, Fang;Zhang, Ke;Wang, Pingqing;Zhang, Baoyun;Kong, Xiangjun;Feng, Guangde;Chu, Mingxing

作者机构：

关键词： MiRNA; Hypothalamus-pituitary axis; GnRH neuron; Reproduction

期刊名称：MOLECULAR AND CELLULAR NEUROSCIENCE （ 影响因子：4.314； 五年影响因子：4.107 ）

ISSN： 1044-7431

年卷期： 2018 年 88 卷

页码：

收录情况： SCI

摘要： The hypothalamic-pituitary-gonz dal (HPG) axis plays a critical role in regulating reproductive function. Gonadotropin-releasing hormone (GnRH), which is secreted by the hypothalamus, acts on pituitary gonado-trophs to stimulate luteinizing hormone (LH) and follicle-stimulating hormone (FSH) synthesis and secretion, ultimately affecting the animal's fertility. MicroRNAs are small, non-coding RNAs that are widely expressed throughout the brain and can fins-tune gene expression post-transcriptionally. Recently, growing evidence has unveiled the central position of miRNAs within a key regulatory process involving GnRH secretion and subsequent activation in the pituitary. Although transcriptional regulation of reproduction has been well studied, the post-transcriptional processes are less well understood. In this review, we elaborate comprehensively on the critical role of miRNAs in the reproductive process, including both temporal and spatial aspects. A better understanding of how miRNAs impart the neuroendocrine system may improve our knowledge of reproduction and provide novel targets for therapeutic development.

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