The roles of cytochrome P450 and P-glycoprotein in the pharmacokinetics of florfenicol in chickens

文献类型： 外文期刊

第一作者： Wang, G. Y.

作者： Wang, G. Y.;Yang, F.;Kong, T.;Zhou, B.;Wang, G. Y.;Jiang, Sh. X.;Zheng, H. H.;Zhang, K. Y.

作者机构：

关键词： CYP 1A; CYP 3A; Florfenicol; P-glycoprotein; pharmacokinetics

期刊名称：IRANIAN JOURNAL OF VETERINARY RESEARCH （ 影响因子：1.376； 五年影响因子：1.346 ）

ISSN： 1728-1997

年卷期： 2018 年 19 卷 1 期

页码：

收录情况： SCI

摘要： The effects of three selective oral inhibitors, fluvoxamine (FLU), ketoconazole (KET), and verapamil (VER), on the pharmacokinetics (PK) of florfenicol (FFC) were investigated in chickens. The chickens were administered orally with saline solution (SAL), FLU (60 mg/kg), KET (25 mg/kg), or VER (9 mg/kg) for 7 consecutive days. Florfenicol was given to the chickens at a single dose of 30 mg/kg orally. Blood samples were collected from each chicken at 0 to 12 h post-administration of FFC. The plasma concentration of FFC was analyzed by high-performance liquid chromatography (HPLC). The AUC of FFC increased and the CLs of FFC decreased with oral co-administration of KET in chickens, and the C-max of FCC increased with VER. While the AUC, the CLs and the C-max FFC were all invariable with FLU. These data suggested that CYP 3A played a key role in the PK of FFC in chickens, however, P-glycoprotein (P-gp) and CYP 1A did not. The results imply that the adverse drug-drug interaction may occur in the use of FFC if the co-administrated drugs are the substrates, inducers or inhibitors of CYP 3A or/and P-gp.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序