DNA N-6-Adenine Methylation in Arabidopsis thaliana

文献类型： 外文期刊

第一作者： Liang, Zhe

作者： Liang, Zhe;Shen, Lisha;Bao, Shengjie;Yu, Hao;Liang, Zhe;Shen, Lisha;Bao, Shengjie;Yu, Hao;Cui, Xuean;Geng, Yuke;Lu, Tiegang;Gu, Xiaofeng;Yu, Guoliang;Liang, Fan;Xie, Shang

作者机构：

期刊名称：DEVELOPMENTAL CELL （ 影响因子：12.27； 五年影响因子：12.332 ）

ISSN： 1534-5807

年卷期： 2018 年 45 卷 3 期

页码：

收录情况： SCI

摘要： DNA methylation on N-6-adenine (6mA) has recently been found to be a potentially epigenetic mark in several unicellular and multicellular eukaryotes. However, its distribution patterns and potential functions in land plants, which are primary producers for most ecosystems, remain largely unknown. Here we report global profiling of 6mA sites at single-nucleotide resolution in the genome of Arabidopsis thaliana at different developmental stages using single-molecule real-time sequencing. 6mA sites are widely distributed across the Arabidopsis genome and enriched over the pericentromeric heterochromatin regions. 6mA occurs more frequently in gene bodies than intergenic regions. Analysis of 6mA methylomes and RNA sequencing data demonstrates that 6mA frequency positively correlates with the gene expression level and the transition from vegetative to reproductive growth in Arabidopsis. Our results uncover 6mA as a DNA mark associated with actively expressed genes in Arabidopsis, suggesting that 6mA serves as a hitherto unknown epigenetic mark in land plants.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序