Chemical composition and antioxidant activity of phenolic compounds from Dioscorea (Yam) leaves

文献类型： 外文期刊

第一作者： Zhou, Li

作者： Zhou, Li;Qin, Zhihong;Zhou, Li;Ren, Xiangmei;Shi, Xinmin

作者机构：

关键词： Microwave-assisted extraction; HPLC-DAD-ESI-MS/MS; phenolic compounds; antioxidant activity; cytoprotective

期刊名称：PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES （ 影响因子：0.684； 五年影响因子：0.804 ）

ISSN： 1011-601X

年卷期： 2018 年 31 卷 3 期

页码：

收录情况： SCI

摘要： This study was aimed to assess the potential of Dioscorea (yam) leaves as a source of antioxidants. Microwave-assisted extraction (MAE) process was used to prepare the extracts. The phenolic compounds in Dioscorea leaves extracts were analyzed by HPLC-DAD-ESI-MS/MS method and the contents of major compounds were determined. Results indicated that a total of 17 phenolic compounds were separated identified by means of UV and mass spectra compared with authentic reference substances and/or reported values in the literature. The main phenolic compound was rosmarinic acid and its highest amount was found in Dioscorea glabra Roxb. leaves (22.31 +/- 1.33 mg/g DW). Rutin was the dominant flavonoid followed by quercetin which highest amount was found in Dioscorea alata leaves (8.66 +/- 0.29 mg/g DW). Antioxidant activity of the extracts was estimated by the use of DPPH and ABTS assays. Both kinds of leaves exhibited satisfied antioxidant capacity which was correlated with phenolic contents. In the cytoprotective effect on HUVECs viability assay, Dioscorea glabra Roxb. leaves extract was found to be more active than that of Dioscorea alata against H2O2-induced oxidative stress. Our findings support the promising role of Dioscorea leaves that can be used as an interesting source of phenolic antioxidants.

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