Reduced graphene oxide and gold nanoparticle composite-based solid-phase extraction coupled with ultra-high-performance liquid chromatography-tandem mass spectrometry for the determination of 9 mycotoxins in milk

文献类型： 外文期刊

第一作者： Jiang, Keqiu

作者： Jiang, Keqiu;Huang, Qingwen;Wu, Yongjiang;Fan, Kai;Nie, Dongxia;Guo, Wenbo;Han, Zheng;Wu, Lidong

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关键词： Milk; Reduced graphene oxide and gold nanoparticle composite; Mycotoxins; Solid-phase extraction; Ultra-high-performance liquid chromatography-tandem mass spectrometry

期刊名称：FOOD CHEMISTRY （ 影响因子：7.514； 五年影响因子：7.516 ）

ISSN： 0308-8146

年卷期： 2018 年 264 卷

页码：

收录情况： SCI

摘要： A reliable solid-phase extraction (SPE) procedure using reduced graphene oxide and gold nanoparticle (rGO/Au) composite as sorbent was proposed for purification and enrichment of aflatoxin B-1 (AFB(1)), aflatoxin M-1 (AFM(1)), ochratoxin A (OTA), zearalenone (ZEA), alpha-zearalenol (alpha-ZOL), beta-zearalenol (beta-ZOL), zearalanone (ZAN), alpha-zearalanol (alpha-ZAL) and beta-zearalanol (beta-ZAL) in milk. Main parameters affecting the performance of SPE procedure were thoroughly investigated. The optimized conditions included 2% acetonitrile in water as the loading solution, 5% methanol in water as the washing solution, and methanol/acetonitrile/formic acid (50/49/1, v/v/v) as the elution solvent. Satisfactory linearity (R-2 >= 0.992), high sensitivity (limit of quantification in the range of 0.02-0.18 ng mL(-1)), adequate recovery (70.2-111.2%), and acceptable precision (RSD, 2.0-14.9%) were obtained when the optimal sample pretreatment protocol was combined with ultra-high-performance liquid chromatography-tandem mass spectrometry detection. The applicability of the validated method was further verified in real milk samples.

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