NMR-based metabolic toxicity of low-level Hg exposure to earthworms

文献类型： 外文期刊

第一作者： Tang, Ronggui

作者： Tang, Ronggui;Ding, Changfeng;Dang, Fei;Zhang, Taolin;Wang, Xingxiang;Ma, Yibing;Wang, Junsong;Tang, Ronggui

作者机构：

关键词： Eisenia fetida; Methylmercury; Histopathological examination; H-1-C-13 NMR; Metabolic net analysis

期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：8.071； 五年影响因子：8.35 ）

ISSN： 0269-7491

年卷期： 2018 年 239 卷

页码：

收录情况： SCI

摘要： Mercury is a globally distributed toxicant to aquatic animals and mammals. However, the potential risks of environmental relevant mercury in terrestrial systems remain largely unclear. The metabolic profiles of the earthworm Eisenia fetida after exposure to soil contaminated with mercury at 0.77 +/- 0.09 mg/kg for 2 weeks were investigated using a two-dimensional nuclear magnetic resonance -based (H-1-C-13 NMR) metabolomics approach. The results revealed that traditional endpoints (e.g., mortality and weight loss) did not differ significantly after exposure. Although histological examination showed sub -lethal toxicity in the intestine as a result of soil ingestion, the underlying mechanisms were unclear. Metabolite profiles revealed significant decreases in glutamine and 2-hexyl-5-ethyl-3-furansulfonate in the exposed group and remarkable increases in glycine, alanine, glutamate, scyllo-inositol, t-methylhistidine and myoinositol. More importantly, metabolic network analysis revealed that low mercury in the soil disrupted osmoregulation, amino acid and energy metabolisms in earthworms. A metabolic net link and schematic diagram of mercury -induced responses were proposed to predict earthworm responses after exposure to mercury at environmental relevant concentrations. These results improved the current understanding of the potential toxicity of low mercury in terrestrial systems. (C) 2018 Elsevier Ltd. All rights reserved.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序