Comparative microRNA-seq Analysis Depicts Candidate miRNAs Involved in Skin Color Differentiation in Red Tilapia

文献类型： 外文期刊

第一作者： Wang, Lanmei

作者： Wang, Lanmei;Zhu, Wenbin;Dong, Zaijie;Fu, Jianjun;Dong, Zaijie;Song, Feibiao;Dong, Juanjuan

作者机构：

关键词： miR-seq; skin color; red tilapia; pigment; comparative analysis

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN： 1422-0067

年卷期： 2018 年 19 卷 4 期

页码：

收录情况： SCI

摘要： Differentiation and variation in body color has been a growing limitation to the commercial value of red tilapia. Limited microRNA (miRNA) information is available on skin color differentiation and variation in fish so far. In this study, a high-throughput Illumina sequencing of sRNAs was conducted on three color varieties of red tilapia and 81,394,491 raw reads were generated. A total of 158 differentially expressed miRNAs (vertical bar log(2)(fold change)vertical bar >= 1 and q-value <= 0.001) were identified. Target prediction and functional analysis of color-related miRNAs showed that a variety of putative target genes-including slc7a11, mc1r and asip-played potential roles in pigmentation. Moreover; the miRNA-mRNA regulatory network was illustrated to elucidate the pigmentation differentiation, in which miR-138-5p and miR-722 were predicted to play important roles in regulating the pigmentation process. These results advance our understanding of the molecular mechanisms of skin pigmentation differentiation in red tilapia.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序