Genome-wide association study reveals novel genes for the ear size in sheep (Ovis aries)

文献类型： 外文期刊

第一作者： Gao, L.

作者： Gao, L.;Yang, J-Q.;Shen, M.;Gao, L.;Yang, J-Q.;Shen, M.;Xu, S-S.;Li, M. -H.;Xu, S-S.;Li, M. -H.

作者机构：

关键词： candidate genes; Duolang sheep; ear development; Ovine Infinium HD BeadChip

期刊名称：ANIMAL GENETICS （ 影响因子：3.169； 五年影响因子：3.058 ）

ISSN： 0268-9146

年卷期： 2018 年 49 卷 4 期

页码：

收录情况： SCI

摘要： Variations in ear size can be observed in livestock such as sheep; however, the genetic basis of variable ear size in sheep is still poorly understood. To investigate causative genes associated with ear size in sheep, a genome-wide association study was performed in 115 adult Duolang sheep with different-sized floppy ears using the Ovine Infinium HD BeadChip. We found 38 significant SNPs at the genome-wide or chromosome-wise 5% significance level after Bonferroni correction. The most significant association (P=1.61x10(-6)) was found at SNP rs402740419, located in the DCC gene, which plays a critical role in ear development. Also, we observed two additional significant SNPs, rs407891215 in PTPRD and rs407769095 in SOX5, both of which are functionally associated with ear developmental processes. Our results are useful for future sheep breeding and provide insights into the genetic basis of ear size development in sheep and other livestock.

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