Antidiabetic Effect of High-Chromium Yeast Against Type 2 Diabetic KK-Ay Mice

文献类型： 外文期刊

第一作者： Liu, Lu

作者： Liu, Lu;Zhang, Shu-wen;Lu, Jing;Pang, Xiao-yang;Lv, Jia-ping

作者机构：

关键词： high-chromium yeast; KK-A(Y) mice; preventive oral administration; spray-dry; type 2 diabetes

期刊名称：JOURNAL OF FOOD SCIENCE （ 影响因子：3.167； 五年影响因子：3.376 ）

ISSN： 0022-1147

年卷期： 2018 年 83 卷 7 期

页码：

收录情况： SCI

摘要： High chromium yeast has attracted many researchers for its high efficiency and high safety among chromium supplements. The preventive effect of oral high-chromium yeast on diabetes was assessed using KK-A(Y) mice. Sixteen-wk-old type 2 diabetic KK-A(Y) mice were divided into five groups and orally administered with two types of drying processed high-chromium yeast, chromium picolinate at 1000g Cr/kg/d, metformin (positive control), and normal yeast (negative control) for 13weeks. The spray-dried high-chromium yeast significantly delayed the onset of hyperglycemia in type 2 diabetic KK-A(Y) mice (P<0.05) and significantly improved fasting blood glucose, TG(triglyceride), and TCHO(total cholesterol) . Histopathological analysis showed that the spray-dried high-chromium yeast led to high affinities for the stains to the -cells in the islets of Langerhans and alleviated hepatic steatosis. High-chromium yeast could be a potential candidate for nutritional supplement to ameliorate diabetes. Practical ApplicationChromium plays an important role in fat and carbohydrate metabolism. The result show that spray-dried high chromium yeast significantly delayed the onset of hyperglycemia in type 2 diabetic KK-A(Y) mice. As one of chromium supplements, the purpose of this study is to examine the efficacy of high chromium yeast on the type 2 diabetes and drying method on its bioactivity, which will be useful for research and development of high-chromium yeast and improvement of pharmacological activity-based quality control.

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