Anchor negatively regulates BMP signalling to control Drosophila wing development

文献类型： 外文期刊

第一作者： Wang, Xiao Chun

作者： Wang, Xiao Chun;Jin, Li Hua;Liu, Ziguang

作者机构：

关键词： BMP pathway; GPR155; CG7510; Wing veins; p-Mad

期刊名称：EUROPEAN JOURNAL OF CELL BIOLOGY （ 影响因子：4.492； 五年影响因子：3.807 ）

ISSN： 0171-9335

年卷期： 2018 年 97 卷 4 期

页码：

收录情况： SCI

摘要： G protein-coupled receptors play particularly important roles in many organisms. The novel Drosophila gene anchor is an orthologue of vertebrate GPR155. However, the roles of anchor in molecular functions and biological processes, especially in wing development, remain unknown. Knockdown of anchor resulted in an increased wing size and additional and thickened veins. These abnormal wing phenotypes were similar to those observed in BMP signalling gain-of-function experiments. We observed that the BMP signalling indicator p-Mad was significantly increased in wing discs in which anchor RNAi was induced in larvae and accumulated abnormally in intervein regions in pupae. Furthermore, the expression of target genes of the BMP signalling pathway was examined using a lacZ reporter, and the results indicated that degrees nib and sal were substantially increased in anchor-knockdown wing discs. An investigation of genetic interactions between Anchor and the BMP signalling pathway revealed that the thickened and ectopic vein tissues were rescued by knocking down BMP levels. These results suggested that Anchor functions to negatively regulate BMP signalling during wing development and vein formation.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序