Low Concentrations of Caffeine and Its Analogs Extend the Lifespan of Caenorhabditis elegans by Modulating IGF-1-Like Pathway

文献类型： 外文期刊

第一作者： Du, Xiaocui

作者： Du, Xiaocui;Guan, Yun;Huang, Qin;Lv, Ming;He, Xiaofang;Fang, Chongye;Wang, Xuanjun;Sheng, Jun;Du, Xiaocui;Guan, Yun;Huang, Qin;Lv, Ming;He, Xiaofang;Fang, Chongye;Wang, Xuanjun;Sheng, Jun;Du, Xiaocui;Guan, Yun;Huang, Qin;Lv, Ming;He, Xiaofang;Yan, Liang;Hayashi, Shuhei;Hayashi, Shuhei;Fang, Chongye;Wang, Xuanjun;Sheng, Jun;Fang, Chongye;Fang, Chongye;Wang, Xuanjun;Sheng, Jun;Wang, Xuanjun

作者机构：

关键词： caffeine; C. elegans; lifespan; IGF-1 pathway; daf-2

期刊名称：FRONTIERS IN AGING NEUROSCIENCE （ 影响因子：5.75； 五年影响因子：5.913 ）

ISSN： 1663-4365

年卷期： 2018 年 10 卷

页码：

收录情况： SCI

摘要： Caffeine has been reported to delay aging and protect aging-associated disorders in Caenorhabditis elegans. However, the effects of low concentration of caffeine and its analogs on lifespan are currently missing. Herein, we report that at much lower concentrations (as low as 10 mu g/ml), caffeine extended the lifespan of C. elegans without affecting food intake and reproduction. The effect of caffeine was dependent on IGF-1-like pathway, although the insulin receptor homolog, daf-2 allele, e1371, was dispensable. Four caffeine analogs, 1-methylxanthine, 7-methylxanthine, 1,3-dimethylxanthine, and 1,7-dimethylxanthine, also extended lifespan, whereas 3-methylxanthine and 3,7-dimethylxanthine did not exhibit lifespan-extending activity.

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