Deletion of the sex-determining gene SXI1 alpha enhances the spread of mitochondrial introns in Cryptococcus neoformans

文献类型： 外文期刊

第一作者： Yan, Zhun

作者： Yan, Zhun;Li, Zhimin;Yan, Li;Yu, Yongting;Cheng, Yi;Chen, Jia;Liu, Yunyun;Gao, Chunsheng;Zeng, Liangbin;Sun, Xiangping;Guo, Litao;Xu, Jianping

作者机构：

关键词： HEG; Intron; Mating type; mtDNA inheritance

期刊名称：MOBILE DNA （ 影响因子：4.06； 五年影响因子：5.82 ）

ISSN： 1759-8753

年卷期： 2018 年 9 卷

页码：

收录情况： SCI

摘要： Background: Homing endonuclease genes (HEGs) are widely distributed genetic elements in the mitochondrial genomes of a diversity of eukaryotes. Due to their ability to self-propagate within and between genomes, these elements can spread rapidly in populations. Whether and how such elements are controlled in genomes remains largely unknown. Results: Here we report that the HEG-containing introns in the mitochondrial COX1 gene in Cryptococcus neoformans are mobile and that their spread in sexual crosses is influenced by mating type (MAT) alpha-specific homeodomain gene SXI1 alpha. C. neoformans has two mating types, MATa and MAT alpha. In typical crosses between strains of the two mating types, only a small portion (< 7%) of diploid fusants inherited the HEGs from the MAT alpha parent. However, disruption of the SXI1 alpha gene resulted in the majority (> 95%) of the diploid fusants inheriting the HEG-containing introns from the MAT alpha parent, a frequency significantly higher than those of intronless mitochondrial genes. Conclusions: Our results suggest that SXI1 alpha not only determines uniparental mitochondrial inheritance but also inhibits the spread of HEG-containing introns in the mitochondrial genome in C. neoformans.

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