文献类型： 外文期刊
第一作者： Ji, Xiaofeng
作者： Ji, Xiaofeng;Xiao, Yi;Liu, Shiyong;Ji, Xiaofeng;Xiao, Yi;Liu, Shiyong;Ji, Xiaofeng
作者机构：
关键词： Na(v)1; 5 pore domain; three-dimensional structure; homology modeling; binding sites; local anesthetic drugs
期刊名称：JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS （ 影响因子：3.31； 五年影响因子：2.689 ）
ISSN： 0739-1102
年卷期： 2018 年 36 卷 9 期
页码：
收录情况： SCI
摘要： The pore domain of human voltage-dependent cardiac sodium channel Na(v)1.5 (hNa(v)1.5) is the crucial binding targets for anti-arrhythmics drugs and some local anesthetic drugs but its three-dimensional structure is still lacking. This has affected the detailed studies of the binding features and mechanism of these drugs. In this paper, we present a structural model for open-state pore domain of hNa(v)1.5 built using single template ROSETTA-membrane homology modeling with the crystal structure of NavMs. The assembled structural models are evaluated by rosettaMP energy and locations of binding sites. The modeled structures of the pore domain of hNa(v)1.5 in open state will be helpful to explore molecular mechanism of a state-dependent drug binding and help designing new drugs.
分类号：
- 相关文献
作者其他论文 更多>>
-
Multi-omics reveals the ecological and biological functions of Enterococcus mundtii in the intestine of lepidopteran insects
作者：Li, Guannan;Wu, Meihong;Xiao, Yi;Tong, Yujie;Zhao, Tianfu;Li, Sheng;Qian, Heying;Qian, Heying
关键词：Enterococcus mundtii; Symbiosis; Intestinal homeostasis; Competitive advantage; Adhesive ability; Silkworm
-
Beneficial efficacy and mode of action of probiotic Bacillus subtilis SWL-19 on the silkworm (Bombyx mori L.)
作者：Li, Guannan;Xiao, Yi;Leng, Jia;Zhao, Tianfu;Lou, Qinian
关键词：Probiotic B. subtilis SWL-19; Antioxidant property; Intestinal immunity; Vitamin B metabolism; Feed additive
-
Virus detection light diffraction fingerprints for biological applications
作者：Li, Tongge;Yang, Ning;Wang, Shihui;Jiang, Feiyang;Zhang, Zhaoyuan;Xiao, Yi;Liu, Yan;Zhang, Xingcai;Pan, Xiaoqing
关键词：
-
Transfer and risk assessment of fipronil in laying hen tissues and eggs
作者：Wang, Zhiwei;Du, Ziyan;Shi, Yanke;Qi, Peipei;Di, Shanshan;Zhao, Huiyu;Ji, Xiaofeng;Wang, Xinquan;Lu, Chunbo
关键词：Fipronil; Laying hens; Drinking water; Feed; Transfer; Residue distribution
-
The fate of Alternaria toxin tenuazonic acid (TeA) during the processing chain of wheat flour products and risk control strategies for mycotoxins
作者：Ji, Xiaofeng;He, Yeyu;Xiao, Yingping;Lyu, Wentao;Yang, Hua;Liang, Ying
关键词：Mycotoxins; Tenuazonic acid; Wheat grain; Flour; Risk assessment; Food safety
-
A tiered approach of hazard-prioritization and risk-ranking for chemical hazards in food commodities: Application for selected mycotoxins
作者：Ji, Xiaofeng;Xiao, Yingping;Lyu, Wentao;Wang, Wen;Yang, Hua;Zhou, Yun;Shao, Kan;Shao, Kan;Yang, Hua
关键词：Risk ranking; Probabilistic MOE; Food contaminants; Infant foods; A tiered approach; Mycotoxins
-
Distribution and safety evaluation of deoxynivalenol and its derivatives throughout the wheat product processing chain
作者：Ji, Xiaofeng;He, Yeyu;Xiao, Yingping;Yang, Hua;Wang, Xiaodan;Liang, Ying;Yang, Weikang;Guo, Cheng;Xiong, Lina;Zhang, Jiahong
关键词：Mycotoxins; Wheat; Food chain; Processing; Food safety; Regulation
