MiR-18a regulates myoblasts proliferation by targeting Fgf1

文献类型： 外文期刊

第一作者： Liu, Chuncheng

作者： Liu, Chuncheng;Meng, Qingyong;Liu, Chuncheng;Chen, Min;Wang, Meng;Lie, Ning;Meng, Qingyong;Liu, Chuncheng;Pi, Wenhui

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2018 年 13 卷 7 期

页码：

收录情况： SCI

摘要： MiRNAs play an important role in cell proliferation, apoptosis, and differentiation. MiR-18a is increasingly being recognized as a regulator of cancer pathogenesis. Here, we discovered that miR-18a participates in myoblasts proliferation. Expression of miR-18a was downregulated with the differentiation of C2C12 myoblasts. Overexpression of miR-18a affected the proliferation of C2C12 cells, primary myoblasts and RD cells. MiR-18a influenced the expression of cell cycle-related genes. Using TargetScan 6.2, we found that the 3' untranslated region (UTR) of the mouse Fgfl gene contains complementary sequences to miR18a. Using a siRNA, we confirmed that the reduction in the Fgf1 levels inhibited proliferation of C2C12 cells. Therefore, our results show that miR-18a participates in the regulation of proliferation by partly decreasing the expression of Fgf1.

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