New insights into the mechanism of phthalate-induced developmental effects

文献类型： 外文期刊

第一作者： Mu, Xiyan

作者： Mu, Xiyan;Huang, Ying;Li, Jia;Yang, Ke;Yang, Wenbo;Shen, Gongming;Li, Xuxing;Lei, Yunlei;Li, Yingren;Pang, Sen;Wang, Chengju;Li, Xuefeng

作者机构：

关键词： Di-(2-ethylhexyl) phthalate; Di-butyl phthalate; Developmental effects; Immune response; Lipid homeostasis; Mechanism

期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：8.071； 五年影响因子：8.35 ）

ISSN： 0269-7491

年卷期： 2018 年 241 卷

页码：

收录情况： SCI

摘要： To investigate the biological pathways involved in phthalate-induced developmental effects, zebrafish embryos were exposed to different concentrations of di-(2-ethylhexyl) (DEHP) and di-butyl phthalate (DBP) for 96 h. Embryonic exposure to DEHP and DBP induced body length decrease, yolk sac abnormities, and immune responses (up-regulation of immune proteins and genes). The lipidomic results showed that at a concentration of 50 mu g/L, DEHP and DBP significantly reduced the levels of fatty acids, triglycerides, diacylglycerol, and cholesterol. These effects are partly explained by biological pathway enrichment based on data from the transcriptional and proteomic profiles. Co-exposure to DBP and ER antagonist did not significantly relieve the toxic symptoms compared with exposure to DBP alone. This indicates that phthalate-induced developmental abnormities in zebrafish might not be mediated by the ER pathway. In conclusion, we identified the possible biological pathways that mediate phthalate-induced developmental effects and found that these effects may not be driven by estrogenic activation. (C) 2018 Elsevier Ltd. All rights reserved.

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