High sequence variation in the exon 10 of TSHR gene is associated with flightless-domestic geese

文献类型： 外文期刊

第一作者： Peng, Qiong

作者： Peng, Qiong;Wang, Ye;Hu, Yaodong;Lan, Dan;Liu, Yiping;He, Daqian;Li, Siming;Lin, Zhenping

作者机构：

关键词： Flightlessness; Domestic geese; TSHR; Relaxed selection

期刊名称：3 BIOTECH （ 影响因子：2.406； 五年影响因子：3.203 ）

ISSN： 2190-572X

年卷期： 2018 年 8 卷 8 期

页码：

收录情况： SCI

摘要： The genetic and molecular mechanisms of the flightless birds without limb modification are rarely reported. To explore the possible reasons for losing flight ability without limb modification, we used the domestic geese as an ideal model to preliminarily study the possible mechanisms for this kind of flightlessness. We compared the sequence variations of the exon 10 of TSHR gene between three domesticated geese populations and two wild ancestor populations. The results showed that domestic geese had higher genetic diversity and more complex population structure than their wild ancestors. We did not detect any population expansion in domestic geese population. However, we detected clear relaxed selection signal and positive selection in domesticated geese groups. Furthermore, special phylogenetic relationship of the exon 10 of TSHR was observed in domesticated geese groups. Combined with its well-established function on metabolic regulation and photoperiod control, we speculate that relaxed selection of TSHR might have effects on flightlessness of domesticated geese.

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