Pharmacokinetics of cefquinome in crucian carp (Carassius auratus gibelio) after oral, intramuscular, intraperitoneal, and bath administration
文献类型： 外文期刊
第一作者： Shan, Q.
作者： Shan, Q.;Ma, L.;Yin, Y.;Liu, S.;Li, L.;Zheng, G.;Shan, Q.;Ma, L.;Yin, Y.;Liu, S.;Li, L.;Zheng, G.;Wang, J.;Yang, F.
作者机构：
关键词： cefquinome; compartment model; Crucian carp; HPLC; pharmacokinetics
期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）
ISSN： 0140-7783
年卷期： 2018 年 41 卷 5 期
页码：
收录情况： SCI
摘要： The pharmacokinetics (PK) of cefquinome (CEQ) was studied in crucian carp (Carassius auratus gibelio) after single oral, intramuscular (i.m.), and intraperitoneal (i.p.) administration at a dose of 10mg/kg body weight and following incubation in a 5mg/L bath for 5hr at 25 degrees C. The plasma concentration of CEQ was determined using high-performance liquid chromatography (HPLC). PK parameters were calculated based on mean CEQ concentration using WinNonlin 6.1 software. The disposition of CEQ following oral, i.m., or i.p. administration was best described by a two-compartment open model with first-order absorption. After oral, i.m., and i.p. administration, the maximum plasma concentration (C-max) values were 1.52, 40.53, and 67.87g/ml obtained at 0.25, 0.23, and 0.35hr, respectively, while the elimination half-life (T-1/2) values were 4.68, 7.39, and 6.88hr, respectively; the area under the concentration-time curve (AUC) values were 8.61, 339.11, and 495.06ghr/ml, respectively. No CEQ was detected in the plasma after bath incubation. Therapeutic blood concentrations of CEQ can be achieved in the crucian carp following i.m. and i.p. administration at a dosage of 10mg/kg once every 2days.
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