Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in Pacific white shrimp Litopenaeus vannamei after multiple-dose oral administration

文献类型： 外文期刊

第一作者： Ma, Rongrong

作者： Ma, Rongrong;Huang, Liang;Wei, Wenjuan;Ma, Rongrong;Huang, Liang;Wei, Wenjuan;Ma, Rongrong;Huang, Liang;Wei, Wenjuan;Ma, Rongrong;Huang, Liang;Wei, Wenjuan;Wang, Yuan;Zou, Xiong;Zhou, Junfang;Li, Xincang;Fang, Wenhong

作者机构：

关键词： Pacific white shrimp; Pharmacokinetics; Enrofloxacin; Ciprofloxacin; Multiple oral administration; In vitro efficacy

期刊名称：FISHERIES SCIENCE （ 影响因子：1.617； 五年影响因子：1.531 ）

ISSN： 0919-9268

年卷期： 2018 年 84 卷 5 期

页码：

收录情况： SCI

摘要： The present study was designed to explore pharmacokinetics (PK) of enrofloxacin and its metabolite ciprofloxacin in Pacific white shrimp Litopenaeus vannamei after multiple-dose oral administration of enrofloxacin (30 mg/kg dose per 12 h and continuous feeding for 3 days). Enrofloxacin and ciprofloxacin concentrations in hemolymph, hepatopancreas, and muscle of the shrimp were simultaneously determined by high-performance liquid chromatography. PK parameters were analyzed based on statistical moment theory. Meanwhile, the relationship of pharmacokinetics/pharmacodynamics (PK/PD) was established based on drug concentration of hemolymph and in vitro antibacterial activity (MIC value). Results showed faster absorption of enrofloxacin in hemolymph (T-max = 1 h) and muscles (T-max = 1 h) than that in hepatopancreas (T-max = 3 h) after the first oral administration. In multiple-dose oral administration, slight accumulation of enrofloxacin occurred in the hemolymph and hepatopancreas, while in the muscle, enrofloxacin concentration showed a significant decline following multiple administration. Tissue distribution of enrofloxacin and ciprofloxacin both followed the order hepatopancreas > hemolymph > muscle, with significantly higher ciprofloxacin concentration in hepatopancreas than in hemolymph (approximately 10-fold) and muscles (approximately 50-fold), indicating that the hepatopancreas is the main organ involved in metabolism of enrofloxacin in Pacific white shrimp. After multiple-dose administration, C-max/MIC and AUC(0-24)/MIC values showed that the therapeutic regimen in this study could be remarkably effective in prevention and treatment of Vibrio infection in Pacific white shrimp.

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