Age-Related Changes in MicroRNA in the Rat Pituitary and Potential Role in GH Regulation

文献类型： 外文期刊

第一作者： Zhang, Haojie

作者： Zhang, Haojie;Chen, Ting;Luo, Junyi;Xi, Qianyun;Jiang, Qingyan;Sun, Jiajie;Zhang, Yongliang;Qi, Qien;Xi, Qianyun;Jiang, Qingyan;Sun, Jiajie;Zhang, Yongliang

作者机构：

关键词： growth hormone; microRNA microarray; pituitary; miR-141-3p

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN： 1422-0067

年卷期： 2018 年 19 卷 7 期

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收录情况： SCI

摘要： The growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis has recently been recognized as an important factor related to the longevity of many organisms. MicroRNAs (miRNAs or miRs) could also participate in diverse biological processes. However, the role of miRNAs in the decline of pituitary GH during the growth process remains unclear. To better characterize the effects of miRNAs on the pituitary, we used a miRNA microarray to investigate the miRNA profile in the rat pituitary from postnatal development throughout the growth process. Then, in vitro experiments were conducted to analyze the miRNAs' potential roles related to GH regulation. Taken together, the microarray results indicated that there were 22 miRNAs differentially expressed during pituitary development. The bioinformatics analysis suggested that the most differentially expressed miRNAs may participate in multiple pathways associated with the pituitary function. Furthermore, the in vitro findings demonstrated that miR-141-3p was involved in GH regulation.

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