Surface molecularly imprinted polymers prepared by two-step precipitation polymerization for the selective extraction of oleanolic acid from grape pomace extract

文献类型： 外文期刊

第一作者： Lu, Chunxia

作者： Lu, Chunxia;Lu, Chunxia;Tang, Zonggui;Liu, Changbin;Ma, Xiaomei

作者机构：

关键词： molecularly imprinted polymers; oleanolic acid; two-step precipitation polymerization

期刊名称：JOURNAL OF SEPARATION SCIENCE （ 影响因子：3.645； 五年影响因子：2.943 ）

ISSN： 1615-9306

年卷期： 2018 年 41 卷 17 期

页码：

收录情况： SCI

摘要： Surface molecularly imprinted polymers were successfully prepared by a novel two-step precipitation polymerization method. The first-step allowed the formation of 4-vinylpyridine divinylbenzene and trimethylolpropane trimethacrylate copolymeric microspheres. In the second-step precipitation polymerization, microspheres were modified with a molecularly imprinting layer of oleanolic acid as template, methacrylic acid as functional monomer, and divinylbenzene/ethylene glycol dimethacrylate as cross-linker. The obtained polymers had an average diameter of 4.43m and a polydispersity index of 1.011; adsorption equilibrium was achieved within 40min, with adsorption capacity reaching 27.4mg/g. Subsequently, the polymers were successfully applied as the adsorbents of molecularly imprinted solid-phase extraction to separateand purifythe oleanolic acid from grape pomace. The content of oleanolic acid in the grape pomace extract was enhanced from 13.4 to 93.2% after using the molecularly imprinted solid-phase extraction process. This work provides an efficient way for effective oleanolic acid separation and enrichment from complex matrices, which is especially valuable in industrial production.

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