Diverse Factors Affecting Efficiency of RNAi in Honey Bee Viruses

文献类型： 外文期刊

第一作者： Yang, Dahe

作者： Yang, Dahe;Xu, Xiang;Yang, Sa;Wang, Xinling;Zhao, Di;Diao, Qingyun;Hou, Chunsheng;Yang, Dahe;Xu, Xiang;Yang, Sa;Wang, Xinling;Zhao, Di;Diao, Qingyun;Hou, Chunsheng;Yang, Dahe;Zhao, Hongxia

作者机构：

关键词： RNAi; honey bee viruses; sensitivity of RNAi; gene function; Apis mellifera

期刊名称：FRONTIERS IN GENETICS （ 影响因子：4.599； 五年影响因子：4.888 ）

ISSN： 1664-8021

年卷期： 2018 年 9 卷

页码：

收录情况： SCI

摘要： Infection and transmission of honey bee viruses pose a serious threat to the pollination services of crops and wild plants, which plays a vital role in agricultural economy and ecology. RNA interference (RNAi) is an effective defense mechanism against commonly occurring viral infections of animals and plants. However, recent studies indicate that the effects of RNAi on the honey bee can induce additional impacts and might not always be effective in suppressing the virus. Moreover, the RNAi responses differed in relation to the developmental stage of the insect and the target tissue used, even though the same method of delivery was used. These results indicate that further analysis and field experiments should be performed to characterize the varying effectiveness of RNAibased methods for treating honey bee viral infections. In this review, we provide an overview of the current knowledge and the recent progress in RNAi-based anti-viral treatments for honey bees, focusing in particular highlight the role of the dsRNA-delivery method used and its effect on RNAi efficiency and demonstrate the potential practical value of this tool for controlling the virus. We conclude studying the gene function and disease control of honey bee by RNAi technology requires a complex consideration from physiology, genetics to environment.

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