文献类型： 外文期刊
第一作者： Peng, Yinghua
作者： Peng, Yinghua;Wang, Xiaohui;Wang, Xiaohui
作者机构：
关键词： Interleukin-1 receptor antagonist; Protein stability; Protein aggregation; Shelf life; Biophysical chemistry
期刊名称：JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS （ 影响因子：3.935； 五年影响因子：3.563 ）
ISSN： 0731-7085
年卷期： 2018 年 160 卷
页码：
收录情况： SCI
摘要： Proteins are labile and their shelf lives are usually months to few years. Herein we report that human interleukin-1 receptor antagonist (IL-1Ra) solution survives ten years. This provides an interesting case that protein biopharmaceutical aqueous solution could be stored for a decade without losing its quality, which could meet the national security needs for 10 years shelf life of biopharmaceuticals. (C) 2018 Elsevier B.V. All rights reserved.
分类号：
- 相关文献
作者其他论文 更多>>
-
Quality and efficiency assessment of five extracellular vesicle isolation methods using the resistive pulse sensing strategy
作者：Yang, Min;Guo, Jia;Chen, Ze;Liu, Ying;Sun, Zepeng;Pang, Xin;Peng, Yinghua;Fang, Le
关键词：
-
Enhanced brain-targeting and efficacy of cannabidiol via RVG-Exo/CBD nanodelivery system
作者：Li, Yingrui;Chen, Ze;Guo, Jia;Meng, Deshuang;Pang, Xin;Sun, Zepeng;Pu, Li;Yang, Shuiyue;Yang, Min;Peng, Yinghua;Pang, Xin;Sun, Zepeng;Pu, Li;Yang, Shuiyue;Peng, Yinghua
关键词：Cannabidiol; Exosomes; Brain-targeted delivery; Drug delivery; RVG
-
Protective Effects of Velvet Antler Methanol Extracts on Hypoxia-Induced Damage in Caenorhabditis elegans through HIF-1 and ECH-8 Mediated Lipid Accumulation
作者：Li, Ru;Peng, Yinghua;Li, Hongyuan;Wang, Xiaohui;Wang, Xiaohui
关键词：velvet antler; hypoxia; HIF-1; lipid accumulation; C. elegans
-
Engineered antler stem cells derived exosomes potentiate anti-tumor efficacy of immune checkpoint inhibitor by reprogramming immunosuppressive tumor microenvironment
作者：Yang, Min;Pu, Li;Yang, Shuiyue;Chen, Ze;Guo, Jia;Liu, Ying;Chang, Shuzhuo;Peng, Yinghua;Pu, Li;Yang, Shuiyue
关键词：ASCs; Exosomes; Poly(I:C); Tumor immunotherapy; PD-L1 antibody
-
GSK3 regulation Wnt/β-catenin signaling affects adipogenesis in bovine skeletal muscle fibro/adipogenic progenitors
作者：Zhang, Junfang;Peng, Yinghua;Zhang, Junfang;Wang, Enze;Li, Qiang;Jin, Huaina;Naseem, Sajida;Sun, Bin;Li, Xiangzi;Choi, Seongho;Park, Sungkwon
关键词：Single -nucleus RNA-sequencing; Wnt/ beta-catenin signaling; Glycogen synthase kinase 3; Fibro/adipogenic progenitor; Intramuscular fat
-
Identification of ARF Genes and Elucidation of the Regulatory Effects of PsARF16a on the Dormancy of Tree Peony Plantlets
作者：Fu, Zhenzhu;Yuan, Xin;Zhao, Yinge;Wang, Huijuan;Li, Yanmin;Gao, Jie;Wang, Limin;Zhang, Hechen;Wang, Xiaohui;Lu, Lin
关键词：tree peony; dormancy; hormone; PsARF
-
Sika Deer Velvet Antler Peptide Exerts Neuroprotective Effect in a Parkinson's Disease Model via Regulating Oxidative Damage and Gut Microbiota
作者：Liu, Ying;Yang, Min;Guo, Jia;Sun, Zepeng;Li, Ru;Pang, Xin;Peng, Yinghua;Li, Hongyuan;Wang, Xiaohui;Sun, Zepeng;Wang, Shuyue;Pang, Xin;Kim, Yumi;Wang, Xiaohui
关键词：Parkinson's disease; velvet antler; peptide; oxidative stress; gut microbiota; neuroprotection
