文献类型： 外文期刊
第一作者： Peng, Yinghua
作者： Peng, Yinghua;Wang, Xiaohui;Wang, Xiaohui
作者机构：
关键词： Interleukin-1 receptor antagonist; Protein stability; Protein aggregation; Shelf life; Biophysical chemistry
期刊名称：JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS （ 影响因子：3.935； 五年影响因子：3.563 ）
ISSN： 0731-7085
年卷期： 2018 年 160 卷
页码：
收录情况： SCI
摘要： Proteins are labile and their shelf lives are usually months to few years. Herein we report that human interleukin-1 receptor antagonist (IL-1Ra) solution survives ten years. This provides an interesting case that protein biopharmaceutical aqueous solution could be stored for a decade without losing its quality, which could meet the national security needs for 10 years shelf life of biopharmaceuticals. (C) 2018 Elsevier B.V. All rights reserved.
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