A 627K variant in the PB2 protein of H9 subtype influenza virus in wild birds

文献类型： 外文期刊

第一作者： Ge, Ye

作者： Ge, Ye;Yao, Qiucheng;Ge, Ye;Deng, Guohua;Chen, Hualan;Ge, Ye;Chai, Hongliang;Hua, Yuping

作者机构：

关键词： epidemiology; H9N2 subtype; influenza virus; phylogeny

期刊名称：INFLUENZA AND OTHER RESPIRATORY VIRUSES （ 影响因子：4.38； 五年影响因子：4.529 ）

ISSN： 1750-2640

年卷期： 2018 年 12 卷 6 期

页码：

收录情况： SCI

摘要： Background Wild birds are gaining increasing attention as gene-mixing reservoirs for influenza viruses. To investigate the molecular properties of the viruses isolated and epidemiological analysis of H9N2 subtype AIV in wild birds, we studied samples obtained over two years (2014-2015) from wetlands in Anhui province, China. Methods A total of 4534 samples were collected from migratory waterfowl in Anhui in 2014-2015, and 8 strains of H9 subtype AIV were isolated. Results Phylogenetic analysis showed different degrees of gene segment reassortment in H9 viruses between the Eurasian lineage and the North American lineage. Most importantly, two viruses harbored the E627K mutation in the polymerase PB2 (PB2) protein. This is the first report of the mutation of this virus from low pathogenicity to high pathogenicity in wild birds. Conclusions The continued surveillance of wild birds, especially migratory birds, is important to provide early warning and control of AIV outbreaks. Our results highlight the high genetic diversity of AIV along the Eurasian-Australian migration flyway and the need for more extensive AIV surveillance in eastern China.

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