Development of water-compatible molecularly imprinted solid-phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry for the detection of six sulfonamides in animal-derived foods

文献类型： 外文期刊

第一作者： Zhao, Xiaolei

作者： Zhao, Xiaolei;Wang, Junping;Wang, Junying;Wang, Shuo

作者机构：

关键词： Sulfonamides; Water-compatible molecularly imprinted polymers; Solid-phase extraction; High performance liquid chromatography tandem mass spectrometry

期刊名称：JOURNAL OF CHROMATOGRAPHY A （ 影响因子：4.759； 五年影响因子：4.302 ）

ISSN： 0021-9673

年卷期： 2018 年 1574 卷

页码：

收录情况： SCI

摘要： A water-compatible molecularly imprinted polymer (MIP) was prepared by combining reversible addition-fragmentation chain transfer (RAFT) with reflux precipitation polymerization (RPP) for solid-phase extraction (SPE) coupled with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to detect six sulfonamides (SAs) in animal-derived foods and water samples. The SEM images indicated the spherical structure of MIP materials. In water medium, MIPs still performed good specific adsorption for SAs. Under the optimized detection conditions, the proposed method offered good linearity (R-2 > 0.996) for the six SAs with relative standard deviation (RSD) for ten replicate extractions of 1.64%-4.68%, limits of detection (S/N = 3) of 0.02 mu g L-1-0.1 mu g L-1 and recoveries of 63.49%-115.72%. Besides, the whole extract process avoided organic solvent consumption, and trace sulfadiazine residues were found in the pork sample at similar concentration of 3.57 and 3.79 mu g kg(-1) using the MIP-SPE method and commercial Oasis HLB cartridge, respectively. It is confirmed the method could be applied to quantitative detect the trace residue sulfonamides in animal-derived samples and water samples. (C) 2018 Elsevier B.V. All rights reserved.

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