Determination of fipronil and its metabolites in eggs by UPLC-QqLIT-MS/MS with multistage mass spectrometry mode

文献类型： 外文期刊

第一作者： Wang, Ni

作者： Wang, Ni;Yang, Guosheng;Wang, Chenchen;Li, Huidong;Fang, Liping;Ding, Ruiyan;Mao, Jiangsheng;Chen, Zilei;Wang, Chenchen;Li, Huidong;Fang, Liping;Ding, Ruiyan;Mao, Jiangsheng;Chen, Zilei;Aboul-Enein, Hassan Y.

作者机构：

关键词： Eggs; Fipronil; Metabolites; Multistage mass spectrometry; Ultra-performance liquid chromatography-quadrupole-linear ion trap mass spectrometry

期刊名称：JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES （ 影响因子：1.312； 五年影响因子：1.145 ）

ISSN： 1082-6076

年卷期： 2018 年 41 卷 9 期

页码：

收录情况： SCI

摘要： A fast, sensitive, and reliable method for the determination of fipronil and its metabolites (fipronil-sulfone, fipronil sulfide, and fipronil-desulfynil) in eggs was developed by a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) pretreatment method and ultra-performance liquid chromatography-quadrupole-linear ion trap mass spectrometry (UPLC-QqLIT-MS/MS). The proposed multistage mass spectrometry (MS3) method provides sufficient sensitivity and excellent reproducibility. The four analytes were separated by a Waters ACQUITY UPLC (R) BEH C18 column and detected by AB Sciex QTRAP((R)) 5500. The mean recoveries for the four analytes ranged from 90.7% to 105% with relative standard deviations (RSDs) of 0.7% to 4.9%. The calibration curve showed a good linearity within the concentration range of 0.05 to 20ng/mL. The correlation coefficients (R-2) were higher than 0.999. The limits of detection (LODs) obtained from the experimental results for fipronil, fipronil-sulfone, fipronil-sulfide, and fipronil-desulfinyl were 0.06, 0.02, 0.05, and 0.04 mu g/kg, respectively. The MS3 method was successfully applied to detect fipronil and its metabolites in 60 egg samples purchased from Chinese supermarkets, and wholesale markets. [GRAPHICS] .

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序