Golden-star nanoparticles as adjuvant effectively promotes immune response to foot-and-mouth disease virus-like particles vaccine
文献类型： 外文期刊
第一作者： Teng, Zhidong
作者： Teng, Zhidong;Sun, Shiqi;Du, Ping;Dong, Hu;Mu, Suyu;Guo, Huichen;Teng, Zhidong;Sun, Shiqi;Du, Ping;Dong, Hu;Mu, Suyu;Guo, Huichen;Chen, Hao;Huang, Jie;Xu, Xiaoyu;Zhang, Zhijun
作者机构：
关键词： Foot-and-mouth disease virus; Virus-like particles; Golden-star nanoparticles; Adjuvant; Vaccination
期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）
ISSN： 0264-410X
年卷期： 2018 年 36 卷 45 期
页码：
收录情况： SCI
摘要： Virus-like particles (VLPs) have become a hot topic in modern vaccine research because of its safety, facile production, and immune properties. To further enhance the immune effect of VLPs, we synthesized and used gold-star nanoparticles (AuSNs) as adjuvant for vaccine. Foot-and-mouth disease (FMD) VLPs as target antigen were combined with AuSNs. The FMD VLPs-AuSNs complex was characterized through sodium dodecyl sulfate-polyacrylamide gel electrophoresis, Western blot, ultraviolet light absorption, and morphological measurement analyses. Result indicated that the FMD VLPs-AuSNs complex is nontoxic in different cell lines. AuSNs can effectively promote the entry of FMD VLPs into cells and improve macrophages activation when combined with FMD VLPs compared with FMD VLPs alone. Further animal vaccination and challenge tests revealed that the specific immune response and protection rate of AuSNs adjuvant group is higher than that of conventional mineral oil (ISA206) adjuvant group. AuSNs can effectively improve the immune protection effects of FMD VLPs vaccines, and exhibit potential as a new adjuvant for other vaccines. (C) 2018 Elsevier Ltd. All rights reserved.
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