Perinatal exposure to low-dose decabromodiphenyl ethane increased the risk of obesity in male mice offspring

文献类型： 外文期刊

第一作者： Yan, Sen

作者： Yan, Sen;Wang, Dezhen;Meng, Zhiyuan;Yan, Jin;Li, Ruisheng;Jia, Ming;Tian, Sinuo;Zhang, Renke;Zhou, Zhiqiang;Zhu, Wentao;Teng, Miaomiao;Yao, Chenyang;Sheng, Jing

作者机构：

关键词： Decabromodiphenyl ethane; Obesity; Metabolomics

期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：8.071； 五年影响因子：8.35 ）

ISSN： 0269-7491

年卷期： 2018 年 243 卷

页码：

收录情况： SCI

摘要： Decabromodiphenyl Ethane (DBDPE), a kind of new brominated flame retardants (NBFRs) used to replace DecaBDE, has been frequently detected in the environment and human samples. In this study, we explored its toxic effects on male mouse offspring after perinatal exposure to DBDPE. During the perinatal period, pregnant ICR mice were exposed to DBDPE (100 mu g/kg body weight) via oral gavage. After weaning, male offspring were fed on a low-fat diet and a high-fat diet, respectively. We measured and recorded body weight, liver weight, and epididymis fat mass, blood biochemical markers, metabolites changes in liver, and gene expression involved in lipid and glucose homeostasis. The results showed that perinatal exposure to DBDPE increased the risk of obesity in mouse offspring and affected triglyceride synthesis, bile secretion, purine synthesis, mitochondrial function and glucose metabolism, furthermore, the use of HFD feeding may further exacerbate these effects. All of these results show that early-life exposure to low doses of DBDPE can promote the development of metabolic dysfunction, which in turn induces obesity. (C) 2018 Elsevier Ltd. All rights reserved.

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