Preparation and characterization of dummy molecularly imprinted polymers for separation and determination of farrerol from Rhododendron aganniphum using HPLC

文献类型： 外文期刊

第一作者： Ma, Xingbin

作者： Ma, Xingbin;Zhang, Jiyu;Zhou, Xuzheng;Ma, Xingbin;Qiu, Cheng;Rabah, Tsdan;Ma, Xingbin;She, Yongxin;Wang, Jing;Ma, Xingbin;Lin, Hongling;Han, Jianchen;He, Qiang

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关键词： Farrerol; quercetin; dummy molecularly imprinted polymer; solid-phase extraction; Rhododendron aganniphum

期刊名称：GREEN CHEMISTRY LETTERS AND REVIEWS （ 影响因子：4.99； 五年影响因子：5.144 ）

ISSN： 1751-8253

年卷期： 2018 年 11 卷 4 期

页码：

收录情况： SCI

摘要： A dummy molecularly imprinted polymer (d-MIP) was developed for extraction and cleanup of farrerol from Rhododendron aganniphum. The d-MIP was prepared by precipitation polymerization using quercetin as the dummy template, 4-vinylpyridine as the functional monomer, ethylene glycol dimethacrylate as the cross-linker, and acetonitrile as the porogen. The d-MIP was characterized by scanning electron microscopy and Fourier-transform infrared spectroscopy. Dynamic curves, adsorption isotherms, and Scatchard plots showed the d-MIP had good affinity, capacity, and selectivity for the target compound. The prepared d-MIP was used as a sorbent in solid-phase extraction cartridges and successfully applied to specific extraction and purification of farrerol from real samples. High recoveries were obtained for four spiked levels of farrerol in Rhododendron aganniphum using d-MIP solid-phase extraction coupled with high-performance liquid chromatography. The linear range was 1-100 mu gmL(-1), the limit of detection was 2.23mgkg(-1), the farrerol recovery range was 85.7%-104.1%, and the relative standard deviations (n=3) were all less than 2.2% for real samples. The proposed method provides a simple, rapid, and environmentally friendly approach to the analysis of farrerol in complex herbal products. [GRAPHICS] .

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