FoxO Transcription Factor Regulate Hormone Mediated Signaling on Nymphal Diapause

文献类型： 外文期刊

第一作者： Yin, Zhen-Juan

作者： Yin, Zhen-Juan;Chen, Hao;Dai, Xiao-Yan;Wu, Guang-An;Zheng, Li;Yu, Yi;Zhai, Yi-Fan;Dong, Xiao-Lin;Wu, Guang-An;Zhai, Yi-Fan;Kang, Kui;Zhai, Yi-Fan

作者机构：

关键词： FoxO; RNAi; nymphal diapause; Laodelphax striatellus; RNA-sequencing (RNA-Seq)

期刊名称：FRONTIERS IN PHYSIOLOGY （ 影响因子：4.566； 五年影响因子：4.804 ）

ISSN： 1664-042X

年卷期： 2018 年 9 卷

页码：

收录情况： SCI

摘要： Diapause is a complex physiological adaptation phenotype, and the transcription factor Forkhead-box O (FoxO) is a prime candidate for activating many of its diverse regulatory signaling pathways. Hormone signaling regulates nymphal diapause in Laodelphax striatellus. Here, the function of the FoxO gene isolated from L. striatellus was investigated. After knocking-down LsFoxO in diapausal nymphs using RNA interference, the titers of juvenile hormone Ill and some cold-tolerance substances decreased significantly, and the duration of the nymphal developmental period was severely shorted to 25.5 days at 20 degrees C under short day-length (10 L:14 D). To determine how LsFoxO affects nymphal diapause, analyses of RNA-sequencing transcriptome data after treatment with LsFoxO-RNA interference was performed. The differentially expressed genes affected carbohydrate, amino acid and fatty acid metabolism, and phosphatidylinositol 3-kinase/protein kinase B signaling pathway. Thus, LsFoxO acts on L. striatellus nymphal diapause and is, therefore, a potential target gene for pest control. This study may lead to new information on the regulation of nymphal diapause in this important pest.

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