Antagonistic Effect of Azoxystrobin Poly (Lactic Acid) Microspheres with Controllable Particle Size on Colletotrichum higginsianum Sacc

文献类型： 外文期刊

第一作者： Yao, Junwei

作者： Yao, Junwei;Cui, Bo;Zhao, Xiang;Zhi, Heng;Zeng, Zhanghua;Wang, Yan;Sun, Changjiao;Liu, Guoqiang;Cui, Haixin;Yao, Junwei;Gao, Jinming

作者机构：

关键词： azoxystrobin; microsphere; Colletotrichum higginsianum Sacc; oxidative damage; antagonistic activity

期刊名称：NANOMATERIALS （ 影响因子：5.076； 五年影响因子：5.346 ）

ISSN： 2079-4991

年卷期： 2018 年 8 卷 10 期

页码：

收录情况： SCI

摘要： Size-controlled azoxystrobin-poly (lactic acid) microspheres (MS) were prepared by an oil/water emulsion solvent evaporation approach. The hydrated mean particle sizes of the MS1, MS2, and MS3 aqueous dispersions were 130.9 nm, 353.4 nm, and 3078.0 nm, respectively. The drug loading and encapsulation efficiency of the azoxystrobin microspheres had a positive relationship with particle size. However, the release rate and percentage of cumulative release were inversely related to particle size. The smaller-sized microspheres had a greater potential to access the target mitochondria. As a result, the more severe oxidative damage of Colletotrichum higginsianum Sacc and higher antagonistic activity were induced by the smaller particle size of azoxystrobin microspheres. The 50% lethal concentrations against Colletotrichum higginsianum Sacc of MS1, MS2, and MS3 were 2.0386 mu g/mL, 12.7246 mu g/mL, and 21.2905 mu g/mL, respectively. These findings reveal that particle size is a critical factor in increasing the bioavailability of insoluble fungicide.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序