Enantioselective Extraction of Phenylalanine Enantiomers Using Environmentally Friendly Aqueous Two-Phase Systems

文献类型： 外文期刊

第一作者： Sun, Danyu

作者： Sun, Danyu;Li, Fenfang;Liu, Lianglei;Tan, Zhijian;Tan, Zhijian;Tan, Zhijian;Wang, Runping

作者机构：

关键词： enantioselective extraction; aqueous two-phase system; ionic liquids; deep eutectic solvents; phenylalanine

期刊名称：PROCESSES （ 影响因子：2.847； 五年影响因子：2.824 ）

ISSN： 2227-9717

年卷期： 2018 年 6 卷 11 期

页码：

收录情况： SCI

摘要： (1) Background: The environmentally friendly choline-amino acid ionic liquids (ChAAILs) and deep eutectic solvents (DESs) have been used as excellent alternatives to volatile organic compounds (VOCs) and ionic liquids (ILs) in recent years; (2) Methods: Thus, ChAAILs/salt and DESs/salt aqueous two-phase systems (ATPSs) were developed for the chiral extraction of phenylalanine enantiomers. The optimum ATPS of [Ch][L-Pro]/K3PO4 was chosen, and the influencing parameters were investigated, including ChAAILs concentration, salt concentration, chiral selector concentration, extraction temperature, phenylalanine concentration, and system pH; (3) Results: The phenylalanine enantiomers were mainly extracted into the top phase (ChAAIL-rich phase), meanwhile, the (S)-phenylalanine [(S)-Phe)] was preferentially recognized by the chiral selector in the top phase. The maximum separation factor () of 2.05 was obtained under the optimal conditions; and (4) Conclusions: This ATPS that was used for the chiral extraction of enantiomers is much more environmentally friendly, simple, and rapid, and has the potential to be used in the enantioselective extraction of other enantiomers.

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