Pharmacokinetic/pharmacodynamic relationship of enrofloxacin against Aeromonas hydrophila in crucian carp (Carassius auratus gibelio)

文献类型： 外文期刊

第一作者： Shan, Qi

作者： Shan, Qi;Wang, Jingxin;Ma, Lisha;Yin, Yi;Liu, Shugui;Li, Lichun;Zheng, Guangming;Shan, Qi;Wang, Jingxin;Ma, Lisha;Yin, Yi;Liu, Shugui;Li, Lichun;Zheng, Guangming;Wang, Jing;Yang, Fenghua;Huang, Ren

作者机构：

关键词： A. hydrophila; crucian carp; enrofloxacin; pharmacokinetic/pharmacodynamics model; pharmacokinetics

期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）

ISSN： 0140-7783

年卷期： 2018 年 41 卷 6 期

页码：

收录情况： SCI

摘要： The pharmacokinetic (PK) properties of enrofloxacin (ENR) and its metabolite ciprofloxacin (CIP) were investigated in crucian carp following oral administration at different dose levels (5, 10, 20, 40 mg/kg body weight). The disposition kinetics of ENR was found to be linear over the dose range studied. Serum half-lives ranged from 64.56 to 72.68 hr. The in vitro and ex vivo activities of ENR in serum against a pathogenic strain of Aeromonas hydrophila were determined. In vitro and ex vivo bactericidal activity of ENR was concentration dependent. Dosing of 10 mg/kg resulted in an AUC/minimum inhibitory concentration (MIC) ratio of 368.92 hr and a C-max/MIC ratio of 7.23, respectively, against A. hydrophila 147 (MIC = 0.48 mu g/ml), indicating a likely high level of effectiveness in clinical infections caused by A. hydrophila with MIC value <= 0.48 mu g/ml. Modeling of ex vivo growth inhibition data to the sigmoid Emax equation provided the values of AUC(24 hr)/MIC required to produce bacteriostasis, bactericidal activity, and elimination of bacteria, these values were 21.70, 53.01, and 125.21 hr, respectively. These findings in conjunction with MIC90 data suggested that ENR at the dose of 7.81 mg/kg predicted a positive clinical outcome and minimize the risk of emergence of resistance.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序