Tissue distribution and elimination features of florfenicol in hybrid sturgeon cultured in cool water

文献类型： 外文期刊

第一作者： Yang, Yuanhao

作者： Yang, Yuanhao;Yang, Juanning;Wang, Lvzhou;Li, Fenggang;Li, Yi;Sun, Yuhang;He, Shuangheng;Wu, Jinxing;Shang, Derong;Li, Fengling

作者机构：

关键词： florfenicol; HPLC-MS; pharmacokinetics; residues; sturgeon

期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.786； 五年影响因子：1.7 ）

ISSN： 0140-7783

年卷期： 2018 年 41 卷 6 期

页码：

收录情况： SCI

摘要： In order to understand pharmacokinetics in vivo and tissue residues of florfenicol in Hybrid sturgeon cultured in cold water, changes in concentration of florfenicol in plasma, muscle, liver and kidney of sturgeon after administration were measured by high performance liquid chromatography mass spectrometry. The results show that after 15.0 mg/kg dose administration, the concentration change in plasma and liver, kidney and muscle of sturgeon are suitable for the one compartment open model. Florfenicol pharmacokinetic parameters in plasma, liver, kidney and sturgeon muscle showed that the peak concentration (C-max) were 549.7, 551.8, 958.2 and 405.4 mu g/kg, respectively. The peak time (T-max) was 17.5, 14.2, 14.0 and 20.8 hr, respectively. The elimination half-life (T-1/2) was 75.1, 99.8, 68.8 and 75.5 hr, respectively. Area under the curve were 70,048.9, 63,850.6, 109,579.9 and 53,437.3 mu g/kg hr, respectively. Mean residence time was 100.6, 96.4, 96.5 and 104.6 hr, respectively. The absorption speed and elimination of florfenicol in cold water cultured sturgeon is slow, and the peak concentration is low, but the florfenicol was widely distributed in the body of sturgeon. The results provide a theoretical basis for formulation of medication and withdrawal period of florfenicol used in sturgeon cultured in cold water.

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