Phosphatidylcholine could protect the defect of zearalenone exposure on follicular development and oocyte maturation

文献类型： 外文期刊

第一作者： Lai, Fang-Nong

作者： Lai, Fang-Nong;Liu, Xue-Lian;Li, Na;Zhang, Rui-Qian;Zhao, Yong;Shen, Wei;Li, Lan;Feng, Yan-Zhong;Nyachoti, Charles Martin

作者机构：

关键词： zearalenone; follicle; oocyte; metabolomics; lysophosphatidylcholine

期刊名称：AGING-US （ 影响因子：5.682； 五年影响因子：6.38 ）

ISSN： 1945-4589

年卷期： 2018 年 10 卷 11 期

页码：

收录情况： SCI

摘要： Zearalenone (ZEA) is a well-known exogenous endocrine disruptor and can lead to severe negative effects on the human and animal reproductive process. Using a follicle culture model, we have previously shown that ZEA exposure significantly affected the follicular development and antrum formation but the underlying mechanisms are not well known. Therefore, in this study, we explored the metabolomic changes of granulosa cell (GC) culture media with or without ZEA exposure. The results showed that ZEA significantly increased phosphatidylcholine or phosphatidyl ethanolamine adducts in culture medium. A comprehensive analysis with the metabolome data from follicular fluid of small and large antral follicles showed that lyso phosphatidylcholine (LPC) was accumulated during follicle growth, but was depleted by ZEA exposure. Exogenous supplement with LPC to the follicle growth media or oocyte maturation media can partly protect the defect of ZEA exposure on follicular antrum formation and oocyte maturation. Taken together, our results demonstrate that ZEA exposure hinders the follicular growth and exogenous LPC can practically protect the defect of ZEA on follicular development and oocyte maturation.

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