Protective effects of lentinan on lipopolysaccharide induced inflammatory response in intestine of juvenile taimen (Hucho taimen, Pallas)

文献类型： 外文期刊

第一作者： Ren, Guangming

作者： Ren, Guangming;Xu, Liming;Lu, Tongyan;Zhang, Yongquan;Wang, Yuanyuan;Yin, Jiasheng

作者机构：

关键词： Hucho taimen; Lentinan; Inflammatory response; Intestinal microbiota

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN： 0141-8130

年卷期： 2019 年 121 卷

页码：

收录情况： SCI

摘要： Antioxidant effects of lentinan on LPS induced inflammatory response in intestine of juvenile taimen were evaluated, and its prebiotic-like efficacy on intestinal microbiota was also investigated. The results showed that LPS decreased the activities of antioxidant enzymes and increased the expression levels of inflammatory cytokines in intestine of juvenile taimen. Dietary lentinan significantly enhanced intestinal antioxidant ability by increasing the activities of SOD, GSH-Px and CAT, and inhibiting the lipid peroxidation in juvenile taimen. Appropriate lentinan prevented the increases in the expression levels of TGF-beta, TNF-alpha, IL1 beta, IL6 and IL8 and ensured the relatively high expression levels of claudin d, SOD, CAT and I kappa B alpha after LPS challenge. Furthermore, dietary lentinan effectively modified intestinal microbiota, represented by increasing the relative abundance of beneficial bacteria such as Lactobacillaceae, Lachnospiraceae and Ruminococcaceae, and decreasing those of detrimental bacteria such as Enterobacteriaceae, Fusobacteriaceae and Flavobacteriaceae. Taken together, dietary lentinan availably decreased LPS induced inflammatory response, indicating that lentinan has the potential anti-inflammatory effects for preventing inflammation diseases in cold-water fish. (C) 2018 Published by Elsevier B.V.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序