文献类型： 外文期刊
第一作者： Li, Xian-Sheng
作者： Li, Xian-Sheng;Zheng, Xin-Heng;Chen, Fang;Zhou, Guang-Xiong;Lin, Bi-Run
作者机构：
关键词： Streptomyces antibiotic; strain identification; streptomyceamide D; cytotoxicity; antifungal activity
期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.569； 五年影响因子：1.598 ）
ISSN： 1028-6020
年卷期： 2018 年 20 卷 8 期
页码：
收录情况： SCI
摘要： An actinomycete strain, H41-55 from sea sediment was identified as Streptomyces antibiotic on the basis of its morphological, physiological and biochemical characteristics as well as 16S rDNA data. A new secondary metabolite, (2S,3R)-N-[3-(formylamino)-2-hydroxybenzoyl]-l-threonine propyl ester (1), together with five known compounds was isolated from fermentation product by use of silica gel and Sephadex LH-20 column chromatography, and preparative RP-C18 HPLC, and identified by HR-TOF-MS and NMR spectra. The cytotoxicities of these isolates against three cancer cell lines and their antifungal activities on Candida albicans were tested. Compounds 1, 3, 5, and 6 displayed moderate cytotoxicity. 5 and 6 showed inhibitory activity on C. albicans. [GRAPHICS] .
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