Residual detection of naproxen, methyltestosterone and 17 alpha-hydroxyprogesterone caproate in aquatic products by simple liquid-liquid extraction method coupled with liquid chromatography-tandem mass spectrometry

文献类型： 外文期刊

第一作者： Zheng, Weijia

作者： Zheng, Weijia;Yoo, Kyung-Hee;Choi, Jeong-Min;Park, Da-Hee;Kim, Seong-Kwan;Kang, Young-Sun;Shin, Ho-Chul;Kang, Young-Sun;Abd El-Aty, A. M.;Abd El-Aty, A. M.;Hacimuftuoglu, Ahmet;Wang, Jing;Shim, Jae-Han

作者机构：

关键词： 17 alpha-hydroxyprogesterone carproate; aquatic product; LC-MS/MS; methyltestosterone; naproxen; residue

期刊名称：BIOMEDICAL CHROMATOGRAPHY （ 影响因子：1.902； 五年影响因子：1.809 ）

ISSN： 0269-3879

年卷期： 2019 年 33 卷 1 期

页码：

收录情况： SCI

摘要： In the present study, we aimed to develop a reliable screening method based on liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) for the detection and quantification of naproxen, methyltestosterone and 17 alpha-hydroxyprogesterone caproate residues. The target analytes were extracted from samples of eel, flatfish and shrimp using acetonitrile with 1% acetic acid, followed by liquid-liquid purification with n-hexane. Chromatographic separation was achieved on a reversed-phase analytical column using 0.1% formic acid containing 10 mm ammonium formate in distilled water (A) and methanol (B) as mobile phases. All the matrix-matched calibration curves were linear (R-2 >= 0.99) over the concentration range of the tested analytes. Recovery at three spiking levels (0.005, 0.01 and 0.02 mg/kg) ranged from 68 to 117% with intra- and inter-day precisions <10%. Five market samples for each matrix (eel, flatfish and shrimp) were collected and tested for method application. In summary, the proposed method is feasible to screen and quantify the analytes with high selectivity in aquatic food products meant for human consumption.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序