Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection

文献类型： 外文期刊

第一作者： Li, Shi-fang

作者： Li, Shi-fang;Gong, Mei-jiao;Zhao, Fu-rong;Shao, Jun-jun;Xie, Yin-li;Zhang, Yong-guang;Chang, Hui-yun;Li, Shi-fang;Zhao, Fu-rong;Shao, Jun-jun;Xie, Yin-li;Zhang, Yong-guang;Chang, Hui-yun;Gong, Mei-jiao

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关键词： Type I IFN classes; Antiviral; Viral infection; Immunodeficiency virus; Hepatitis; Influenza Virus

期刊名称：CELLULAR PHYSIOLOGY AND BIOCHEMISTRY （ 影响因子：5.5； 五年影响因子：4.354 ）

ISSN： 1015-8987

年卷期： 2018 年 51 卷 5 期

页码：

收录情况： SCI

摘要： The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surface. The type I IFNs are the largest group and include IFN-alpha, IFN-beta, IFN-epsilon, IFN-omega, IFN-kappa, IFN-delta, IFN-tau and IFN-zeta. The use of IFNs for the treatment of viral infectious diseases on their antiviral activity may become an important therapeutic option, for example, IFN-alpha is well known for the successful treatment of hepatitis B and C virus infections, and interest is increasing in the antiviral efficacy of other novel IFN classes and their potential applications. Therefore, in this review, we summarize the recent progress in the study of the biological activities of all the type I IFN classes and their potential applications in the treatment of infections with immunodeficiency virus, hepatitis viruses, and influenza viruses.

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